Protein arginine methyltransferases: promising targets for cancer therapy
JW Hwang, Y Cho, GU Bae, SN Kim… - Experimental & molecular …, 2021 - nature.com
Protein methylation, a post-translational modification (PTM), is observed in a wide variety of
cell types from prokaryotes to eukaryotes. With recent and rapid advancements in epigenetic …
cell types from prokaryotes to eukaryotes. With recent and rapid advancements in epigenetic …
Epigenetic tools (The Writers, The Readers and The Erasers) and their implications in cancer therapy
S Biswas, CM Rao - European journal of pharmacology, 2018 - Elsevier
Addition of chemical tags on the DNA and modification of histone proteins impart a distinct
feature on chromatin architecture. With the advancement in scientific research, the key …
feature on chromatin architecture. With the advancement in scientific research, the key …
Recent developments and applications of the MMPBSA method
The Molecular Mechanics Poisson-Boltzmann Surface Area (MMPBSA) approach has been
widely applied as an efficient and reliable free energy simulation method to model molecular …
widely applied as an efficient and reliable free energy simulation method to model molecular …
PRMTs and arginine methylation: cancer's best-kept secret?
J Jarrold, CC Davies - Trends in molecular medicine, 2019 - cell.com
Post-translational modification (PTM) of proteins is vital for increasing proteome diversity
and maintaining cellular homeostasis. If the writing, reading, and removal of modifications …
and maintaining cellular homeostasis. If the writing, reading, and removal of modifications …
Inhibitors of protein methyltransferases and demethylases
Post-translational modifications of histones by protein methyltransferases (PMTs) and
histone demethylases (KDMs) play an important role in the regulation of gene expression …
histone demethylases (KDMs) play an important role in the regulation of gene expression …
[HTML][HTML] Chemical biology of protein arginine modifications in epigenetic regulation
J Fuhrmann, KW Clancy, PR Thompson - Chemical reviews, 2015 - ACS Publications
Post-translational modifications (PTMs) of histone proteins are a hallmark of epigenetic
regulation. They provide a mechanism to modulate chromatin structure and constitute the …
regulation. They provide a mechanism to modulate chromatin structure and constitute the …
CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1 signaling and tumor growth
The mammalian target of rapamycin complex1 (mTORC1) is a central regulator of
metabolism and cell growth by sensing diverse environmental signals, including amino …
metabolism and cell growth by sensing diverse environmental signals, including amino …
Protein arginine methyltransferases: insights into the enzyme structure and mechanism at the atomic level
Protein arginine methyltransferases (PRMTs) catalyze the methyl transfer to the arginine
residues of protein substrates and are classified into three major types based on the final …
residues of protein substrates and are classified into three major types based on the final …
Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing
RBM15, an RNA binding protein, determines cell-fate specification of many tissues including
blood. We demonstrate that RBM15 is methylated by protein arginine methyltransferase 1 …
blood. We demonstrate that RBM15 is methylated by protein arginine methyltransferase 1 …
Small molecule inhibitors of protein arginine methyltransferases
Introduction: Arginine methylation is an abundant posttranslational modification occurring in
mammalian cells and catalyzed by protein arginine methyltransferases (PRMTs) …
mammalian cells and catalyzed by protein arginine methyltransferases (PRMTs) …