Nuclear factor‐κB (NF‐κB) and mitogen‐activated protein kinase (MAPK) activation play
central roles in the induction of gene expression in innate immune cells following pathogen …

The IκB kinase (IKK) complex plays a well-documented role in innate and adaptive
immunity. This function has been widely attributed to its role as the central activator of the NF …

Pediatric-onset colitis and inflammatory bowel disease (IBD) have significant effects on the
growth of infants and children, but the etiopathogenesis underlying disease subtypes …

Nearly two decades after the initial cloning and identification of the founding father of the
tumor necrosis factor receptor (TNFR) family, much has been learned about the mechanisms …

Tumor progression locus-2 (Tpl2) kinase is a major inflammatory mediator in immune cell
types recently found to be genetically associated with inflammatory bowel diseases (IBDs) …

KRAS is one of the driver oncogenes in non-small-cell lung cancer (NSCLC) but remains
refractory to current modalities of targeted pathway inhibition, which include inhibiting …

The activation of mitogen-activated protein kinases (MAPKs) is critically involved in
inflammatory and oncogenic events. Tumor progression locus 2 (Tpl2), also known as COT …

The tumor microenvironment plays a significant role in colitis-associated cancer (CAC).
Intestinal myofibroblasts (IMFs) are cells in the intestinal lamina propria secreting factors that …

Tpl2 (Tumor progression locus 2), also known as Cot/MAP3K8, is a hematopoietically
expressed serine-threonine kinase. Tpl2 is known to have critical functions in innate …

Patients with triple-negative breast cancer (TNBC) have a poor prognosis, partly because of
the absence of targeted therapies. Recognition of the key role of immune responses against …