As the most common chronic degenerative joint disease, osteoarthritis (OA) is the leading
cause of pain and physical disability, affecting millions of people worldwide. Mainly …

Osteoarthritis (OA) involves all the structures of the joint. How the disease is initiated and
what factors trigger the disease process remain unclear, although the mechanical …

Objective Mechanical factors, in particular increased medial knee joint load, are believed to
be important in the structural progression of knee osteoarthritis. This study evaluated the …

Obesity-related osteoarthritis (OA) is a complex, multifactorial condition that can cause
significant impact on patients' quality of life. Whilst chronic inflammation, adipocytokines and …

Mechanical loading to the knee joint results in a differential response based on the local
capacity of the tissues (ligament, tendon, meniscus, cartilage, and bone) and how those …

The articular cartilage and the subchondral bone form a biocomposite that is uniquely
adapted to the transfer of loads across the diarthrodial joint. During the evolution of the …

Objective To determine the effect of an intensive weight loss program on knee joint loads
during walking in obese patients with knee osteoarthritis (OA). Methods Participants …

Objective To investigate relationships between external knee adduction moment parameters
(KAM) and osteoarthritis (OA) symptoms according to disease severity. Design 164 …

Biofeedback assisted rehabilitation and intervention technologies have the potential to
modify clinically relevant biomechanics. Gait retraining has been used to reduce the knee …

The subchondral bone is involved in the pathophysiology of osteoarthritis (OA), both by
biochemical and mechanical pathways. Overloaded OA subchondral bone osteoblasts …