Mitochondrial transfer/transplantation: an emerging therapeutic approach for multiple diseases

Z Liu, Y Sun, Z Qi, L Cao, S Ding - Cell & bioscience, 2022 - Springer
Mitochondria play a pivotal role in energy generation and cellular physiological processes.
These organelles are highly dynamic, constantly changing their morphology, cellular …

Mitochondrial dysfunction is a common denominator linking skeletal muscle wasting due to disease, aging, and prolonged inactivity

HW Hyatt, SK Powers - Antioxidants, 2021 - mdpi.com
Skeletal muscle is the most abundant tissue in the body and is required for numerous vital
functions, including breathing and locomotion. Notably, deterioration of skeletal muscle …

[HTML][HTML] Nasal administration of mitochondria reverses chemotherapy-induced cognitive deficits

JF Alexander, AV Seua, LD Arroyo, PR Ray… - Theranostics, 2021 - ncbi.nlm.nih.gov
Up to seventy-five percent of patients treated for cancer suffer from cognitive deficits which
can persist for months to decades, severely impairing quality of life. Although the number of …

[HTML][HTML] Delivery of mitochondria confers cardioprotection through mitochondria replenishment and metabolic compliance

A Zhang, Y Liu, J Pan, F Pontanari, ACH Chang… - Molecular Therapy, 2023 - cell.com
Mitochondrial dysfunction is a hallmark of heart failure. Mitochondrial transplantation has
been demonstrated to be able to restore heart function, but its mechanism of action remains …

Intranasal delivery of mitochondria for treatment of Parkinson's Disease model rats lesioned with 6-hydroxydopamine

JC Chang, YC Chao, HS Chang, YL Wu, HJ Chang… - Scientific Reports, 2021 - nature.com
The feasibility of delivering mitochondria intranasally so as to bypass the blood–brain barrier
in treating Parkinson's disease (PD), was evaluated in unilaterally 6-OHDA-lesioned rats …

Mitochondrial transplantation attenuates neural damage and improves locomotor function after traumatic spinal cord injury in rats

MW Lin, SY Fang, JYC Hsu, CY Huang… - Frontiers in …, 2022 - frontiersin.org
Mitochondrial dysfunction is a hallmark of secondary neuroinflammatory responses and
neuronal death in spinal cord injury (SCI). Even though mitochondria-based therapy is an …

Prospects of mitochondrial transplantation in clinical medicine: Aspirations and challenges

S Hosseinian, PA Pour, A Kheradvar - Mitochondrion, 2022 - Elsevier
Mitochondria, known as the powerhouse of the cell, are at the center of healthy physiology
and provide cells with energy in the form of ATP. These unique organelles are also …

The diversity and coexistence of extracellular mitochondria in circulation: A friend or foe of the immune system

A Caicedo, K Zambrano, S Sanon, JL Vélez… - Mitochondrion, 2021 - Elsevier
The diversity and coexistence of extracellular mitochondria may have a key role in the
maintenance of health and progression of disease. Studies report that active mitochondria …

Mitochondrial transplantation: a critical analysis

BV Chernyak - Biochemistry (Moscow), 2020 - Springer
Abstract “Mitochondrial transplantation” refers to a procedure for introducing isolated
mitochondria into a damaged area of a heart or other organ. A considerable amount of data …

Mitochondrion-targeted antioxidant SkQ1 prevents rapid animal death caused by highly diverse shocks

VP Skulachev, MY Vyssokikh, BV Chernyak… - Scientific Reports, 2023 - nature.com
The response to stress involves the activation of pathways leading either to protection from
the stress origin, eventually resulting in development of stress resistance, or activation of the …