Hematopoietic cell kinase (Hck) is a member of the Src family and is expressed in
hematopoietic cells. By regulating multiple signaling pathways, HCK can interact with …

Hematopoietic cell kinase (Hck), a non-receptor tyrosine kinase belonging to the Src kinase
family, is intricately linked to the pathogenesis of numerous human diseases, with a …

Chemotherapy resistance is the dominant challenge in the treatment of acute myeloid
leukemia (AML). Nuclear factor E2–related factor 2 (Nrf2) exerts a vital function in drug …

The bone marrow (BM) microenvironment (niche) is abnormally altered in acute myeloid
leukemia (AML), leading to deficient secretion of proteins, soluble factors, and cytokines by …

Background: Oncostatin M (OSM) is involved in several inflammatory responses.
Tryptanthrin (TRYP), as a natural alkaloid, is a bioactive compound derived from indigo …

Aberrant signaling pathways regulating proliferation and differentiation of hematopoietic
stem cells (HSCs) can contribute to disease pathogenesis and neoplastic growth …

Myeloid neoplasms result from molecular alterations in hematopoietic stem cells, with acute
myeloid leukemia (AML) being one of the most aggressive and with a poor prognosis …

Background β-carboline alkaloids exert a distinguished ability to impair cell growth and
induce cell death in a variety of cancers and the evaluation of such new therapeutic …

We investigated role of haematopoietic cell kinase (Hck) in osteoarthritis (OA) and to explore
the underlying mechanisms driving its effects. An OA animal model was established and …

Diabetic retinopathy (DR), a major complication of diabetes causing blindness, is
characterized by retinal damage due to capillary degeneration and vascular leakage …