Abstract Development of the retinal vasculature is based on highly coordinated signalling
between different cell types of the retina, integrating internal metabolic requirements with …

Mechanisms and Management of Retinopathy of Prematurity | New England Journal of Medicine
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Purpose: To establish a normative database for vascular density (VD) and foveal avascular
zone (FAZ) at the superficial (SCP) and deep capillary plexus (DCP) in healthy subjects with …

We review the cellular and physiological mechanisms responsible for the regulation of blood
flow in the retina and choroid in health and disease. Due to the intrinsic light sensitivity of the …

The blood-retinal barrier (BRB) regulates transport across retinal capillaries maintaining
proper neural homeostasis and protecting the neural tissue from potential blood borne …

The vascular endothelial growth factor (VEGF) family of growth factors controls pathological
angiogenesis and increased vascular permeability in important eye diseases such as …

The retinal and cerebral microvasculatures share many morphological and physiological
properties. Assessment of the cerebral microvasculature requires highly specialized and …

Often those diseases most evasive to therapeutic intervention usurp the human body's own
cellular machinery or deregulate normal physiological processes for propagation. Tumor …

Collectively, angiogenic ocular conditions represent the leading cause of irreversible vision
loss in developed countries. In the US, for example, retinopathy of prematurity, diabetic …

Blood vessels that supply the inner portion of the retina are extensively reorganized during
development. The vessel regression, sprouting angiogenesis, vascular remodelling and …