Biotin-dependent carboxylases include acetyl-CoA carboxylase (ACC), propionyl-CoA
carboxylase (PCC), 3-methylcrotonyl-CoA carboxylase (MCC), geranyl-CoA carboxylase …

Amide bond-containing (ABC) biomolecules are some of the most intriguing and functionally
significant natural products with unmatched utility in medicine, agriculture and …

Pyruvate carboxylase (PC) is a tetrameric enzyme that contains two active sites per subunit
that catalyze two consecutive reactions. A mobile domain with an attached prosthetic biotin …

Biotin (vitamin B7) is involved in a wide range of essential biochemical reactions and a
crucial micronutrient that is vital for many pro-and eukaryotic organisms. The few biotin …

Biotin is the major cofactor involved in carbon dioxide metabolism. Indeed, biotin‐dependent
enzymes are ubiquitous in nature and are involved in a myriad of metabolic processes …

The activity of the biotin-dependent enzyme pyruvate carboxylase from many organisms is
highly regulated by the allosteric activator acetyl-CoA. A number of X-ray crystallographic …

Methylene‐1, 3‐dioxolan‐2‐ones underwent oxidative addition of a Ni0 catalyst in the
presence of Me2Al (OMe), followed by a coupling reaction with alkynes, to form δ, ϵ …

Pyruvate carboxylase (PC) catalyzes the ATP-dependent carboxylation of pyruvate to
oxaloacetate, an important anaplerotic reaction in mammalian tissues. To effect catalysis …

Allosteric regulation of the essential anaplerotic enzyme, pyruvate carboxylase (PC), is vital
for metabolic homeostasis. PC catalyzes the bicarbonate-and ATP-dependent carboxylation …

Pyruvate carboxylase is a metabolic enzyme that fuels the tricarboxylic acid cycle with one of
its intermediates and also participates in the first step of gluconeogenesis. This large …