Increased metabolic potential, efficacy, and safety of emerging treatments in schizophrenia
JM Meyer, CU Correll - CNS drugs, 2023 - Springer
Patients with schizophrenia experience a broad range of detrimental health outcomes
resulting from illness severity, heterogeneity of disease, lifestyle behaviors, and adverse …
resulting from illness severity, heterogeneity of disease, lifestyle behaviors, and adverse …
A Novel Gliotransmitter, L-β-Aminoisobutyric Acid, Contributes to Pathophysiology of Clinical Efficacies and Adverse Reactions of Clozapine
K Fukuyama, E Motomura, M Okada - Biomolecules, 2023 - mdpi.com
Clozapine is listed as one of the most effective antipsychotics and has been approved for
treating treatment-resistant schizophrenia (TRS); however, several type A and B adverse …
treating treatment-resistant schizophrenia (TRS); however, several type A and B adverse …
[HTML][HTML] Ketogenic Diet Intervention on Metabolic and Psychiatric Health in Bipolar and Schizophrenia: A Pilot Trial
S Sethi, D Wakeham, T Ketter, F Hooshmand… - Psychiatry …, 2024 - Elsevier
The ketogenic diet (KD, also known as metabolic therapy) has been successful in the
treatment of obesity, type 2 diabetes, and epilepsy. More recently, this treatment has shown …
treatment of obesity, type 2 diabetes, and epilepsy. More recently, this treatment has shown …
In vivo techniques for assessment of insulin sensitivity and glucose metabolism
Metabolic tests are vital to determine in vivo insulin sensitivity and glucose metabolism in
preclinical models, usually rodents. Such tests include glucose tolerance tests, insulin …
preclinical models, usually rodents. Such tests include glucose tolerance tests, insulin …
Antipsychotic-induced dysregulation of glucose metabolism through the central nervous system: a scoping review of animal models
E Au, KJ Panganiban, S Wu, K Sun, B Humber… - Biological Psychiatry …, 2024 - Elsevier
The use of antipsychotic drugs is associated with adverse metabolic effects. Disruptions in
glucose metabolism such as hyperglycemia and insulin resistance have been shown to …
glucose metabolism such as hyperglycemia and insulin resistance have been shown to …
Olanzapine's effects on hypothalamic transcriptomics and kinase activity
S Pereira, LN Castellani, C Kowalchuk… - …, 2024 - Elsevier
Olanzapine is a second-generation antipsychotic that disrupts metabolism and is associated
with an increased risk of type 2 diabetes. The hypothalamus is a key region in the control of …
with an increased risk of type 2 diabetes. The hypothalamus is a key region in the control of …
Intranasal insulin increases brain glutathione (GSH) and enhances antioxidant capacity in healthy participants, but not in those with early psychotic disorders.
Background We examined the acute effects of intranasal insulin on cognitive function and
brain glutathione, a central factor in resistance to oxidative stress, in both participants with …
brain glutathione, a central factor in resistance to oxidative stress, in both participants with …
Allyl isothiocyanate, a TRPA1 agonist, protects against olanzapine-induced hypothalamic and hepatic metabolic aberrations in female mice
Olanzapine, a widely prescribed atypical antipsychotic, poses a great risk to the patient's
health by fabricating a plethora of severe metabolic and cardiovascular adverse effects …
health by fabricating a plethora of severe metabolic and cardiovascular adverse effects …
Neuronal alterations in AKT isotype expression in schizophrenia
Schizophrenia is characterized by substantial alterations in brain function, and previous
studies suggest insulin signaling pathways, particularly involving AKT, are implicated in the …
studies suggest insulin signaling pathways, particularly involving AKT, are implicated in the …
Development of novel tools for dissection of central versus peripheral dopamine D2-like receptor signaling in dysglycemia
Dopamine (DA) D2-like receptors in both the central nervous system (CNS) and the
periphery are key modulators of metabolism. Moreover, disruption of D2-like receptor …
periphery are key modulators of metabolism. Moreover, disruption of D2-like receptor …