Structural biology of SARS-CoV-2: open the door for novel therapies

W Yan, Y Zheng, X Zeng, B He, W Cheng - Signal Transduction and …, 2022 - nature.com
Abstract Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the causative
agent of the pandemic disease COVID-19, which is so far without efficacious treatment. The …

Aging in COVID-19: Vulnerability, immunity and intervention

Y Chen, SL Klein, BT Garibaldi, H Li, C Wu… - Ageing research …, 2021 - Elsevier
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic was first
reported in Wuhan, China in December 2019, moved across the globe at an unprecedented …

Intranasal vaccines for SARS-CoV-2: From challenges to potential in COVID-19 management

VP Chavda, LK Vora, AK Pandya, VB Patravale - Drug discovery today, 2021 - Elsevier
Abstract Unlike conventional Coronavirus 2019 (COVID-19) vaccines, intranasal vaccines
display a superior advantage because the nasal mucosa is often the initial site of infection …

SARS-CoV-2 mutations and their viral variants

B Cosar, ZY Karagulleoglu, S Unal, AT Ince… - Cytokine & growth factor …, 2022 - Elsevier
Mutations in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) occur
spontaneously during replication. Thousands of mutations have accumulated and continue …

Hyperinflammatory immune response and COVID-19: a double edged sword

LY Tan, TV Komarasamy… - Frontiers in …, 2021 - frontiersin.org
The coronavirus disease-19 (COVID-19) elicited by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) has caused devastating health, economic and social impact …

SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formation

DW Sanders, CC Jumper, PJ Ackerman, D Bracha… - Elife, 2021 - elifesciences.org
Many enveloped viruses induce multinucleated cells (syncytia), reflective of membrane
fusion events caused by the same machinery that underlies viral entry. These syncytia are …

COVID-19: characteristics and therapeutics

R Chilamakuri, S Agarwal - Cells, 2021 - mdpi.com
Novel coronavirus (COVID-19 or 2019-nCoV or SARS-CoV-2), which suddenly emerged in
December 2019 is still haunting the entire human race and has affected not only the …

Targeting transcriptional regulation of SARS-CoV-2 entry factors ACE2 and TMPRSS2

Y Qiao, XM Wang, R Mannan… - Proceedings of the …, 2021 - National Acad Sciences
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for
COVID-19, employs two key host proteins to gain entry and replicate within cells …

Interactions of SARS-CoV-2 with the blood–brain barrier

MA Erickson, EM Rhea, RC Knopp… - International Journal of …, 2021 - mdpi.com
Emerging data indicate that neurological complications occur as a consequence of severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The blood–brain barrier …

Biosurfactants: The green generation of speciality chemicals and potential production using Solid-State fermentation (SSF) technology

IM Banat, Q Carboue, G Saucedo-Castaneda… - Bioresource …, 2021 - Elsevier
Surfactants are multipurpose products found in most sectors of contemporary industry. Their
large-scale manufacturing has been mainly carried out using traditional chemical processes …