New progress in the pharmacology of protocatechuic acid: A compound ingested in daily foods and herbs frequently and heavily

J Song, Y He, C Luo, B Feng, F Ran, H Xu, Z Ci… - Pharmacological …, 2020 - Elsevier
Protocatechuic acid is a natural phenolic acid, which widely exists in our daily diet and
herbs. It is also one of the main metabolites of complex polyphenols, such as anthocyanins …

Antioxidant effects of protocatechuic acid and protocatechuic aldehyde: old wine in a new bottle

S Zhang, Z Gai, T Gui, J Chen… - Evidence‐Based …, 2021 - Wiley Online Library
Phenolic compounds are naturally present as secondary metabolites in plant‐based
sources such as fruits, vegetables, and spices. They have received considerable attention …

Dietary anti-aging polyphenols and potential mechanisms

J Luo, H Si, Z Jia, D Liu - Antioxidants, 2021 - mdpi.com
For years, the consumption of a diet rich in fruits and vegetables has been considered
healthy, increasing longevity, and decreasing morbidities. With the assistance of basic …

Pharmacological properties of polyphenols: Bioavailability, mechanisms of action, and biological effects in in vitro studies, animal models, and humans

K Stromsnes, R Lagzdina, G Olaso-Gonzalez… - Biomedicines, 2021 - mdpi.com
Drugs are bioactive compounds originally discovered from chemical structures present in
both the plant and animal kingdoms. These have the ability to interact with molecules found …

Insulin resistance is cheerfully hitched with hypertension

S Sinha, M Haque - Life, 2022 - mdpi.com
Cardiovascular diseases and type 2 diabetes mellitus (T2DM) have risen steadily
worldwide, particularly in low-income and developing countries. In the last hundred years …

Polydatin: pharmacological mechanisms, therapeutic targets, biological activities, and health benefits

A Karami, S Fakhri, L Kooshki, H Khan - Molecules, 2022 - mdpi.com
Polydatin is a natural potent stilbenoid polyphenol and a resveratrol derivative with
improved bioavailability. Polydatin possesses potential biological activities predominantly …

Role of dietary polyphenols in the activity and expression of nitric oxide synthases: A review

G Serreli, M Deiana - Antioxidants, 2023 - mdpi.com
Nitric oxide (NO) plays several key roles in the functionality of an organism, and it is usually
released in numerous organs and tissues. There are mainly three isoforms of the enzyme …

Nutritional Value, Phytochemical Potential, and Therapeutic Benefits of Pumpkin (Cucurbita sp.)

M Batool, MMAN Ranjha, U Roobab, MF Manzoor… - Plants, 2022 - mdpi.com
Pumpkin is a well-known multifunctional ingredient in the diet, full of nutrients, and has
opened new vistas for scientists during the past years. The fruit of pumpkin including the …

[HTML][HTML] Implication of dietary phenolic acids on inflammation in cardiovascular disease

SS Ali, WANW Ahmad, SB Budin… - Reviews in …, 2020 - imrpress.com
In spite of medical advances, cardiovascular disease remains a significant concern,
imposing a great burden upon the economy and public health of nations by causing the …

The use of bioactive compounds in hyperglycemia-and amyloid fibrils-induced toxicity in type 2 diabetes and Alzheimer's disease

AV Lupaescu, M Iavorschi, M Covasa - Pharmaceutics, 2022 - mdpi.com
It has become increasingly apparent that defective insulin signaling may increase the risk for
developing Alzheimer's disease (AD), influence neurodegeneration through promotion of …