The global public health crisis caused by COVID-19 has lasted longer than many of us
would have hoped and expected. With its high uncertainty and limited control, the COVID-19 …

There is a large and growing body of evidence on the health benefits of engagement in
leisure activities (voluntary, enjoyable non-work activities, such as hobbies, arts …

Life history theory argues that exposure to early life adversity (ELA) accelerates
development, although existing evidence for this varies. We present a meta-analysis and …

Introduction Adverse childhood experiences are associated with the development of
substance use disorders. With opioid use disorder, a growing concern in the United States …

DNA methylation likely plays a role in the regulation of human stress reactivity. Here we
show that in a genome-wide analysis of blood DNA methylation in 85 healthy individuals, a …

Abstract DNA methylation, through 5-methyl-and 5-hydroxymethylcytosine (5mC and 5hmC),
is considered to be one of the principal interfaces between the genome and our …

There is a growing body of research focused on the relationship between childhood trauma
and the risk of developing psychosis. Numerous studies, including many large-scale …

Epigenetic differences may help to distinguish between PTSD cases and trauma-exposed
controls. Here, we describe the results of the largest DNA methylation meta-analysis of …

Exposure to psychological trauma is a strong risk factor for several debilitating disorders
including post-traumatic stress disorder (PTSD) and depression. Besides the impact on …

In order to determine the impact of the epigenetic response to traumatic stress on post-
traumatic stress disorder (PTSD), this study examined longitudinal changes of genome-wide …