Epigenetic mechanisms control gene expression during normal development and their
aberrant regulation may lead to human diseases including cancer. Natural phytochemicals …

Inflammation and autophagy are cellular defense mechanisms. When these processes are
deregulated (deficient or overactivated) they produce pathologic effects, such as oxidative …

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal human cancers and
shows resistance to any therapeutic strategy used. Here we tested small-molecule inhibitors …

As one of the most aggressive and lethal human malignancies with extremely poor
prognosis, there is an urgent demand of more effective therapy for the treatment of …

UHRF1 (ubiquitin like with plant homeodomain and ring finger domains 1) is an epigenetic
modifier that is overexpressed in some cancers, including pancreatic cancer, and mediates …

Pancreatic cancer is the fourth leading cause of cancer death in the US and is expected to
become the second leading cause of cancer-related deaths in the next decade. Despite 5 …

Interleukin-6 is an important pro-inflammatory cytokine strongly linked to the most burdened
exocrine pancreatic diseases including acute pancreatitis, chronic pancreatitis and …

Bromodomain inhibitors (JQ1 and I-BET 762) are a new generation of selective, small
molecule inhibitors that target BET (bromodomain and extra terminal) proteins. By impairing …

Sažetak Epigenetic mechanisms, such as DNA methylation, DNA hydroxymethylation, post-
translational modifications (PTMs) of histone proteins affecting nucleosome remodelling …

An improvement in pancreatic cancer treatment represents an urgent medical goal. Late
diagnosis and high intrinsic resistance to conventional chemotherapy has led to a dismal …