Acetaminophen (APAP) hepatotoxicity because of overdose is the most frequent cause of
acute liver failure in the western world. Metabolic activation of APAP and protein adduct …

Acetaminophen (N-acetyl-para-aminophenol; APAP) overdose is the most common cause of
acute liver failure in the Western world, with limited treatment opportunities. For years …

Drug-induced liver injury is an important clinical problem and a challenge for drug
development. Whereas progress in understanding rare and unpredictable (idiosyncratic) …

Liver sinusoidal endothelial cells (LSECs) have long been noted to contribute to liver
regeneration after liver injury. In normal liver, the major cellular source of HGF is the hepatic …

Acetaminophen (APAP) overdose results in acute liver failure and has limited treatment
options. Previous studies show that stimulating liver regeneration is critical for survival after …

Acetaminophen (APAP) was first synthesized in the 1800s, and came on the market
approximately 65 years ago. Since then, it has become one of the most used drugs in the …

Acetaminophen (APAP) is the most popular mild analgesic and antipyretic drug used
worldwide. APAP overdose leads to drug-induced hepatotoxicity and can cause hepatic …

Acetaminophen (APAP)-induced injury is a common clinical phenomenon that not only
occurs in a dose-dependent manner but also occurs in some idiosyncratic individuals in a …

Liver, the major metabolic organ in the body, is known for its remarkable capacity to
regenerate. Whereas partial hepatectomy (PHx) is a popular model for the study of liver …

Conclusions: These data show that HNF4α interacts with Nrf2 and promotes glutathione
replenishment aiding in recovery from APAP-induced liver injury, a process inhibited by …