Biomarkers used in Alzheimer's disease diagnosis, treatment, and prevention
YAR Mahaman, KS Embaye, F Huang, L Li, F Zhu… - Ageing research …, 2022 - Elsevier
Abstract Alzheimer's disease (AD), being the number one in terms of dementia burden, is an
insidious age-related neurodegenerative disease and is presently considered a global …
insidious age-related neurodegenerative disease and is presently considered a global …
Neurofilaments at a glance
Neurofilaments (NFs) are intermediate filaments with a diameter of 10 nm, similar to that of
neurons. Although they are present in perikarya and dendrites, neurofilaments are …
neurons. Although they are present in perikarya and dendrites, neurofilaments are …
Fibrin gels and their clinical and bioengineering applications
Fibrin gels, prepared from fibrinogen and thrombin, the key proteins involved in blood
clotting, were among the first biomaterials used to prevent bleeding and promote wound …
clotting, were among the first biomaterials used to prevent bleeding and promote wound …
Keratins significantly contribute to cell stiffness and impact invasive behavior
K Seltmann, AW Fritsch, JA Käs… - Proceedings of the …, 2013 - National Acad Sciences
Cell motility and cell shape adaptations are crucial during wound healing, inflammation, and
malignant progression. These processes require the remodeling of the keratin cytoskeleton …
malignant progression. These processes require the remodeling of the keratin cytoskeleton …
Intermediate filaments: primary determinants of cell architecture and plasticity
H Herrmann, SV Strelkov, P Burkhard… - The Journal of clinical …, 2009 - Am Soc Clin Investig
Intermediate filaments (IFs) are major constituents of the cytoskeleton and nuclear boundary
in animal cells. They are of prime importance for the functional organization of structural …
in animal cells. They are of prime importance for the functional organization of structural …
Intermediate filaments take the heat as stress proteins
DM Toivola, P Strnad, A Habtezion, MB Omary - Trends in cell biology, 2010 - cell.com
Intermediate filament (IF) proteins and heat shock proteins (HSPs) are large multimember
families that share several features, including protein abundance, significant upregulation in …
families that share several features, including protein abundance, significant upregulation in …
Measuring the mechanical properties of living cells using atomic force microscopy
G Thomas, NA Burnham… - Journal of visualized …, 2013 - pmc.ncbi.nlm.nih.gov
Mechanical properties of cells and extracellular matrix (ECM) play important roles in many
biological processes including stem cell differentiation, tumor formation, and wound healing …
biological processes including stem cell differentiation, tumor formation, and wound healing …
Cerebrospinal fluid neurofilament light concentration predicts brain atrophy and cognition in Alzheimer's disease
Introduction This study assessed the utility of cerebrospinal fluid (CSF) neurofilament light
(NfL) in Alzheimer's disease (AD) diagnosis, its association with amyloid and tau pathology …
(NfL) in Alzheimer's disease (AD) diagnosis, its association with amyloid and tau pathology …
High stretchability, strength, and toughness of living cells enabled by hyperelastic vimentin intermediate filaments
In many developmental and pathological processes, including cellular migration during
normal development and invasion in cancer metastasis, cells are required to withstand …
normal development and invasion in cancer metastasis, cells are required to withstand …
Toward unraveling the complexity of simple epithelial keratins in human disease
MB Omary, NO Ku, P Strnad… - The Journal of clinical …, 2009 - Am Soc Clin Investig
Simple epithelial keratins (SEKs) are found primarily in single-layered simple epithelia and
include keratin 7 (K7), K8, K18–K20, and K23. Genetically engineered mice that lack SEKs …
include keratin 7 (K7), K8, K18–K20, and K23. Genetically engineered mice that lack SEKs …