Biomarkers used in Alzheimer's disease diagnosis, treatment, and prevention

YAR Mahaman, KS Embaye, F Huang, L Li, F Zhu… - Ageing research …, 2022 - Elsevier
Abstract Alzheimer's disease (AD), being the number one in terms of dementia burden, is an
insidious age-related neurodegenerative disease and is presently considered a global …

Neurofilaments at a glance

A Yuan, MV Rao, RA Nixon - Journal of cell science, 2012 - journals.biologists.com
Neurofilaments (NFs) are intermediate filaments with a diameter of 10 nm, similar to that of
neurons. Although they are present in perikarya and dendrites, neurofilaments are …

Fibrin gels and their clinical and bioengineering applications

PA Janmey, JP Winer… - Journal of the Royal …, 2009 - royalsocietypublishing.org
Fibrin gels, prepared from fibrinogen and thrombin, the key proteins involved in blood
clotting, were among the first biomaterials used to prevent bleeding and promote wound …

Keratins significantly contribute to cell stiffness and impact invasive behavior

K Seltmann, AW Fritsch, JA Käs… - Proceedings of the …, 2013 - National Acad Sciences
Cell motility and cell shape adaptations are crucial during wound healing, inflammation, and
malignant progression. These processes require the remodeling of the keratin cytoskeleton …

Intermediate filaments: primary determinants of cell architecture and plasticity

H Herrmann, SV Strelkov, P Burkhard… - The Journal of clinical …, 2009 - Am Soc Clin Investig
Intermediate filaments (IFs) are major constituents of the cytoskeleton and nuclear boundary
in animal cells. They are of prime importance for the functional organization of structural …

Intermediate filaments take the heat as stress proteins

DM Toivola, P Strnad, A Habtezion, MB Omary - Trends in cell biology, 2010 - cell.com
Intermediate filament (IF) proteins and heat shock proteins (HSPs) are large multimember
families that share several features, including protein abundance, significant upregulation in …

Measuring the mechanical properties of living cells using atomic force microscopy

G Thomas, NA Burnham… - Journal of visualized …, 2013 - pmc.ncbi.nlm.nih.gov
Mechanical properties of cells and extracellular matrix (ECM) play important roles in many
biological processes including stem cell differentiation, tumor formation, and wound healing …

Cerebrospinal fluid neurofilament light concentration predicts brain atrophy and cognition in Alzheimer's disease

K Dhiman, VB Gupta, VL Villemagne… - Alzheimer's & …, 2020 - Wiley Online Library
Introduction This study assessed the utility of cerebrospinal fluid (CSF) neurofilament light
(NfL) in Alzheimer's disease (AD) diagnosis, its association with amyloid and tau pathology …

High stretchability, strength, and toughness of living cells enabled by hyperelastic vimentin intermediate filaments

J Hu, Y Li, Y Hao, T Zheng, SK Gupta… - Proceedings of the …, 2019 - National Acad Sciences
In many developmental and pathological processes, including cellular migration during
normal development and invasion in cancer metastasis, cells are required to withstand …

Toward unraveling the complexity of simple epithelial keratins in human disease

MB Omary, NO Ku, P Strnad… - The Journal of clinical …, 2009 - Am Soc Clin Investig
Simple epithelial keratins (SEKs) are found primarily in single-layered simple epithelia and
include keratin 7 (K7), K8, K18–K20, and K23. Genetically engineered mice that lack SEKs …