Phenomenology of the initial burst release of drugs from PLGA microparticles

J Yoo, YY Won - ACS Biomaterials Science & Engineering, 2020 - ACS Publications
Poly (lactic-co-glycolic acid)(PLGA) is the most prevalent polymer drug delivery vehicle in
use today. There are about 20 commercialized drug products in which PLGA is used as an …

Degradable controlled-release polymers and polymeric nanoparticles: mechanisms of controlling drug release

N Kamaly, B Yameen, J Wu, OC Farokhzad - Chemical reviews, 2016 - ACS Publications
The development of biodegradable polymers represents a revolution in medicine spanning
over 50 years and leading to significant biotechnological advancements in drug delivery …

PLGA/PLA-based long-acting injectable depot microspheres in clinical use: production and characterization overview for protein/peptide delivery

A Butreddy, RP Gaddam, N Kommineni… - International journal of …, 2021 - mdpi.com
Over the past few decades, long acting injectable (LAI) depots of polylactide-co-glycolide
(PLGA) or polylactic acid (PLA) based microspheres have been developed for controlled …

Electrospun amorphous solid dispersions of poorly water-soluble drugs: A review

DG Yu, JJ Li, GR Williams, M Zhao - Journal of controlled release, 2018 - Elsevier
The development of oral dosage forms for poorly water-soluble active pharmaceutical
ingredients (APIs) is a persistent challenge. A range of methods has been explored to …

Poly (lactic acid)/poly (lactic-co-glycolic acid)-based microparticles: An overview

P Blasi - Journal of Pharmaceutical Investigation, 2019 - Springer
Background Poly (glycolic acid), poly (lactic acid) and poly (lactic-co-glycolic acid) were
approved by the United States Food and Drug Administration (FDA) in the 1970s as …

The mechanisms of drug release in poly (lactic-co-glycolic acid)-based drug delivery systems—A review

S Fredenberg, M Wahlgren, M Reslow… - International journal of …, 2011 - Elsevier
Abstract Poly (d, l-lactic-co-glycolic acid)(PLGA) is the most frequently used biodegradable
polymer in the controlled release of encapsulated drugs. Understanding the release …

Glass transition temperature of PLGA particles and the influence on drug delivery applications

G Liu, K McEnnis - Polymers, 2022 - mdpi.com
Over recent decades, poly (lactic-co-glycolic acid)(PLGA) based nano-and micro-drug
delivery vehicles have been rapidly developed since PLGA was approved by the Food and …

Principles of encapsulating hydrophobic drugs in PLA/PLGA microparticles

C Wischke, SP Schwendeman - International Journal of pharmaceutics, 2008 - Elsevier
Injectable biodegradable and biocompatible copolymers of lactic and glycolic acid (PLGA)
are an important advanced delivery system for week-to-month controlled release of …

Recent development in nanoencapsulation and delivery of natural bioactives through chitosan scaffolds for various biological applications

N Yadav, D Mudgal, R Anand, S Jindal… - International journal of …, 2022 - Elsevier
Nowadays, nano/micro-encapsulation as a pioneering technique may significantly improve
the bioavailability and durability of Natural bioactives. For this purpose, chitosan as a …

Co‐electrospun poly(lactide‐co‐glycolide), gelatin, and elastin blends for tissue engineering scaffolds

M Li, MJ Mondrinos, X Chen, MR Gandhi… - … Research Part A, 2006 - Wiley Online Library
In this study, we describe composite scaffolds composed of synthetic and natural materials
with physicochemical properties suitable for tissue engineering applications. Fibrous …