Background Substance use disorder (SUD) remains a significant public health issue. A
greater understanding of how genes and environment interact to regulate phenotypes …

Abstract Purpose of Review With the advent of the genome-wide association study (GWAS),
our understanding of the genetics of addiction has made significant strides forward. Here …

Here we report a large genome-wide association study (GWAS) for longitudinal smoking
phenotypes in 286,118 individuals from the Million Veteran Program (MVP) where we …

Cannabis is the most frequently used illicit psychoactive substance worldwide; around one
in ten users become dependent. The risk for cannabis use disorder (CUD) has a strong …

Chronic obstructive pulmonary disease (COPD) is a common and progressive disease that
is influenced by both genetic and environmental factors. For many years, knowledge of the …

Background Addictive disorders are a class of chronic, relapsing mental disorders that are
responsible for increased risk of mental and medical disorders and represent the largest …

Cigarette smoking is a leading cause of preventable mortality worldwide. Nicotine
dependence, which reduces the likelihood of quitting smoking, is a heritable trait with firmly …

Genomic research is one of the tools for elucidating the pathogenesis of diseases of global
health relevance and paving the research dimension to clinical and public health translation …

Nicotine dependence is highly comorbid with schizophrenia, and the etiology of the
comorbidity is unknown. To determine whether there is a genetic correlation of smoking …

We conducted a 1000 Genomes–imputed genome-wide association study (GWAS) meta-
analysis for nicotine dependence, defined by the Fagerström Test for Nicotine Dependence …