The Many Faces of Vitamin B12: Catalysis by Cobalamin-Dependent Enzymes
R Banerjee, SW Ragsdale - Annual review of biochemistry, 2003 - annualreviews.org
▪ Abstract Vitamin B12 is a complex organometallic cofactor associated with three
subfamilies of enzymes: the adenosylcobalamin-dependent isomerases, the …
subfamilies of enzymes: the adenosylcobalamin-dependent isomerases, the …
Cobalt: its role in health and disease
K Yamada - Interrelations between essential metal ions and human …, 2013 - Springer
The primarily function of cobalt in humans is based on its role in cobalamin (Cbl, vitamin B
12). Therefore, this chapter will focus on the physiological roles of Cbl and the importance of …
12). Therefore, this chapter will focus on the physiological roles of Cbl and the importance of …
Mutualistic interactions between vitamin B12‐dependent algae and heterotrophic bacteria exhibit regulation
E Kazamia, H Czesnick, TTV Nguyen… - Environmental …, 2012 - Wiley Online Library
Many algae are auxotrophs for vitamin B12 (cobalamin), which they need as a cofactor for
B12‐dependent methionine synthase (METH). Because only prokaryotes can synthesize the …
B12‐dependent methionine synthase (METH). Because only prokaryotes can synthesize the …
How a Protein Binds B12: A 3.0 Å X-Ray Structure of B12-Binding Domains of Methionine Synthase
CL Drennan, S Huang, JT Drummond, RG Matthews… - Science, 1994 - science.org
The crystal structure of a 27-kilodalton methylcobalamin-containing fragment of methionine
synthase from Escherichia coli was determined at 3.0 Å resolution. This structure depicts …
synthase from Escherichia coli was determined at 3.0 Å resolution. This structure depicts …
STRUCTURE-BASED PERSPECTIVES ON B12-DEPENDENT ENZYMES
ML Ludwig, RG Matthews - Annual review of biochemistry, 1997 - annualreviews.org
Two X-ray structures of cobalamin (B12) bound to proteins have now been determined.
These structures reveal that the B12 cofactor undergoes a major conformational change on …
These structures reveal that the B12 cofactor undergoes a major conformational change on …
Cobalamin-dependent methyltransferases
RG Matthews - Accounts of Chemical Research, 2001 - ACS Publications
Cobalamin cofactors play critical roles in radical-catalyzed rearrangements and in methyl
transfers. This Account focuses on the role of methylcobalamin and its structural …
transfers. This Account focuses on the role of methylcobalamin and its structural …
Purification, kinetic properties, and cDNA cloning of mammalian betaine-homocysteine methyltransferase
TA Garrow - Journal of Biological Chemistry, 1996 - ASBMB
Porcine liver betaine-homocysteine methyltransferase (BHMT; EC) was purified to
homogeneity, and the Michaelis constants for betaine, dimethylacetothetin, and L …
homogeneity, and the Michaelis constants for betaine, dimethylacetothetin, and L …
Methanol and methyl group conversion in acetogenic bacteria: biochemistry, physiology and application
F Kremp, V Müller - FEMS Microbiology Reviews, 2021 - academic.oup.com
The production of bulk chemicals mostly depends on exhausting petroleum sources and
leads to emission of greenhouse gases. Within the last decades the urgent need for …
leads to emission of greenhouse gases. Within the last decades the urgent need for …
Differences in the efficiency of reductive activation of methionine synthase and exogenous electron acceptors between the common polymorphic variants of human …
H Olteanu, T Munson, R Banerjee - Biochemistry, 2002 - ACS Publications
Methionine synthase reductase (MSR) catalyzes the conversion of the inactive form of
human methionine synthase to the active state of the enzyme. This reaction is of paramount …
human methionine synthase to the active state of the enzyme. This reaction is of paramount …
Genetic disorders of vitamin B12 metabolism: eight complementation groups–eight genes
DS Froese, RA Gravel - Expert reviews in molecular medicine, 2010 - cambridge.org
Vitamin B12 (cobalamin, Cbl) is an essential nutrient in human metabolism. Genetic
diseases of vitamin B12 utilisation constitute an important fraction of inherited newborn …
diseases of vitamin B12 utilisation constitute an important fraction of inherited newborn …