Normal circulatory function is a key determinant of disease-free life expectancy (healthspan).
Indeed, pathologies affecting the cardiovascular system, which are growing in prevalence …

Endothelial cells are located at the crucial interface between circulating blood and semi-
solid tissues and have many important roles in maintaining systemic physiological function …

INTRODUCTION All body cells rely on blood vessels (BVs) for the provision of oxygen and
other blood-borne substances and, in certain settings, also for the provision of endothelial …

Aging of the vasculature plays a central role in morbidity and mortality of older people. To
develop novel treatments for amelioration of unsuccessful vascular aging and prevention of …

Advancing age promotes cardiovascular disease (CVD), the leading cause of death in the
United States and many developed nations. Two major age-related arterial phenotypes …

Background: Type 2 diabetes mellitus (T2DM) has emerged as a pandemic. It has different
complications, both microvascular and macrovascular. Objective: The purpose of this review …

Endothelial cells (ECs) are more than inert blood vessel lining material. Instead, they are
active players in the formation of new blood vessels (angiogenesis) both in health and (life …

Cardiovascular disease (CVD) presents a great burden for elderly patients, their caregivers,
and health systems. Structural and functional alterations of vessels accumulate throughout …

Diabetes is a significant health problem worldwide, and its association with cardiovascular
disease (CVD) was reported in several studies. Hyperglycemia and insulin resistance seen …

Age is one of the major risk factors associated with cardiovascular disease (CVD). About
one‐fifth of the world population will be aged 65 or older by 2030, with an exponential …