Skeletal muscle possesses a remarkable regenerative capacity that relies on the activity of
muscle stem cells, also known as satellite cells. The presence of non-myogenic cells also …

Satellite cells are adult myogenic stem cells that repair damaged muscle. The enduring
capacity for muscle regeneration requires efficient satellite cell expansion after injury, their …

Prolonged expression of the CRISPR-Cas9 nuclease and gRNA from viral vectors may
cause off-target mutagenesis and immunogenicity. Thus, a transient delivery system is …

Biomarkers for monitoring of disease progression and response to therapy are lacking for
muscle diseases such as Duchenne muscular dystrophy. Noninvasive in vivo molecular …

Skeletal muscle has the capacity of regeneration after injury. However, for large volumes of
muscle loss, this regeneration needs interventional support. Consequently, muscle injury …

Striated muscle is a highly plastic and regenerative organ that regulates body movement,
temperature, and metabolism—all the functions needed for an individual's health and well …

Duchenne muscular dystrophy (DMD) is a severe, progressive, and ultimately fatal disease
of skeletal muscle wasting, respiratory insufficiency, and cardiomyopathy. The identification …

Abstract The C57BL/10ScSn-Dmd mdx/J (BL10-mdx) mouse has been the most commonly
used model for Duchenne muscular dystrophy (DMD) for decades. Their muscle dysfunction …

Recent years have seen tremendous progress towards therapy of many previously incurable
neuromuscular diseases. This new context has acted as a driving force for the development …

A few animal models of Duchenne muscular dystrophy (DMD) are available, large ones
such as pigs or dogs being expensive and difficult to handle. Mdx (X-linked muscular …