Mechanisms leading to COX-2 expression and COX-2 induced tumorigenesis: topical therapeutic strategies targeting COX-2 expression and activity
A Telliez, C Furman, N Pommery… - Anti-Cancer Agents in …, 2006 - ingentaconnect.com
The biological role of COX-2, the inducible form of cyclooxygenase, is to convert arachidonic
acid into prostaglandins (PGs) and thromboxanes (TXs). Overexpressed in many tumors …
acid into prostaglandins (PGs) and thromboxanes (TXs). Overexpressed in many tumors …
[HTML][HTML] The emerging role of endothelin-1 in the pathogenesis of subchondral bone disturbance and osteoarthritis
Mounting evidence suggests reconceptualizing osteoarthritis (OA) as an inflammatory
disorder. Trauma and obesity, the common risk factors of OA, could trigger the local or …
disorder. Trauma and obesity, the common risk factors of OA, could trigger the local or …
Inhibition of cyclooxygenase-1 and-2 expression by targeting the endothelin a receptor in human ovarian carcinoma cells
F Spinella, L Rosano, V Di Castro, MR Nicotra… - Clinical Cancer …, 2004 - AACR
Abstract Purpose and Experimental Design: New therapies against cancer are based on
targeting cyclooxygenase (COX)-2. Activation of the endothelin A receptor (ETAR) by …
targeting cyclooxygenase (COX)-2. Activation of the endothelin A receptor (ETAR) by …
Endothelin-1 downregulates angiotensin-converting enzyme-2 expression in human bronchial epithelial cells
H Zhang, Y Li, Y Zeng, R Wu, J Ou - Pharmacology, 2013 - karger.com
Background/Aims: Both endothelin-1 (ET-1) and the renin-angiotensin system (RAS) are
implicated in the pathogenesis and progression of chronic obstructive pulmonary disease …
implicated in the pathogenesis and progression of chronic obstructive pulmonary disease …
Endothelin-1 down-regulates the expression of vascular endothelial growth factor-A associated with osteoprogenitor proliferation and differentiation
CJH Veillette, HP Von Schroeder - Bone, 2004 - Elsevier
Endothelin-1 (ET-1) is implicated in the signaling between vascular endothelial cells (VECs)
and osteoblasts during bone development, remodeling and repair. Vascular endothelial …
and osteoblasts during bone development, remodeling and repair. Vascular endothelial …
Prostaglandin F2α: a bone remodeling mediator
D Agas, L Marchetti, MM Hurley… - Journal of Cellular …, 2013 - Wiley Online Library
Prostaglandin F2α (PGF2α) plays multiple roles on bone metabolism by regulating a wide
range of signaling pathways. PGF2α, via activation of PKC, stimulates Na‐dependent …
range of signaling pathways. PGF2α, via activation of PKC, stimulates Na‐dependent …
Rho and Rho Kinase Are Involved in Parathyroid Hormone‐Stimulated Protein Kinase C α Translocation and IL‐6 Promoter Activity in Osteoblastic Cells
JM Radeff, Z Nagy, PH Stern - Journal of bone and mineral …, 2004 - academic.oup.com
The role of small G‐proteins in PTH‐stimulated PKC translocation and IL‐6 promoter
expression in UMR‐106 cells was determined. The effects of PTH (1–34) and PTH (3–34) in …
expression in UMR‐106 cells was determined. The effects of PTH (1–34) and PTH (3–34) in …
Endothelin-1 in osteoarthritic chondrocytes triggers nitric oxide production and upregulates collagenase production
CA Manacu, J Martel-Pelletier, M Roy-Beaudry… - Arthritis Res Ther, 2005 - Springer
The mechanism of endothelin-1 (ET-1)-induced nitric oxide (NO) production, MMP-1
production and MMP-13 production was investigated in human osteoarthritis chondrocytes …
production and MMP-13 production was investigated in human osteoarthritis chondrocytes …
Pentoxifylline-induced protein expression change in RAW 264.7 cells as determined by immunoprecipitation-based high performance liquid chromatography
Although pentoxifylline (PTX) was identified as a competitive non-selective
phosphodiesterase inhibitor, its pharmacological effect has not been clearly elucidated. The …
phosphodiesterase inhibitor, its pharmacological effect has not been clearly elucidated. The …
[HTML][HTML] Phospholipase D1 activity is crucial for cytosolic phospholipase A2–dependent prostaglandin E2 formation in murine osteoblastic MC3T3-E1 cells
HJ Leis, W Windischhofer - Prostaglandins, Leukotrienes and Essential …, 2023 - Elsevier
In bone, prostaglandin E 2 (PGE 2) is highly osteogenic and formed by osteoblasts, a key
modulatory event in the regulation of bone cell activity. MC3T3-E1 cells are widely used as …
modulatory event in the regulation of bone cell activity. MC3T3-E1 cells are widely used as …