Reperfusion therapy is critical for saving heart muscle after myocardial infarction, but the
process of restoring blood flow can itself exacerbate injury to the myocardium. This …

Exosomes or so-called natural nanoparticles have recently shown enormous potential for
targeted drug delivery systems. Several studies have reported that exosomes as advanced …

Milk-derived extracellular vesicles (mEVs) are emerging as promising therapeutic
candidates due to their unique properties and versatile functions. These vesicles play a …

Most orally administered drugs struggle to reach intracerebral regions due to the intestinal
epithelial barrier (IEB) and blood–brain barrier (BBB). In this study, we investigate the …

Rationale: Oral chemotherapy has been emerging as a hopeful therapeutic regimen for the
treatment of various cancers because of its high safety and convenience, lower costs, and …

Peripherally injected local anesthetics exhibit limited ability to penetrate peripheral nerve
barriers, which limits their effectiveness in peripheral nerve block and increases the risk of …

Formulating drugs into nanoparticles that target sites of disease can lead to strong
therapeutic effects with lower doses of drugs and lower rates of off-target adverse effects …

Lung cancer is one of the major cancer types and poses challenges in its treatment,
including lack of specificity and harm to healthy cells. Nanoparticle-based drug delivery …

Background Breast cancer is the most prevalent malignant tumor among women, with
hormone receptor-positive cases constituting 70%. Fulvestrant, an antagonist for these …

Abstract Fibroblast growth factor 21 (FGF21) shows great therapeutic potential in metabolic,
neurodegenerative and inflammatory diseases. However, current FGF21 administration …