Targeting drugs to tumours using cell membrane-coated nanoparticles

RH Fang, W Gao, L Zhang - Nature Reviews Clinical Oncology, 2023 - nature.com
Traditional cancer therapeutics, such as chemotherapies, are often limited by their non-
specific nature, causing harm to non-malignant tissues. Over the past several decades …

Tumor-associated macrophages in cancer: recent advancements in cancer nanoimmunotherapies

N Kumari, SH Choi - Journal of Experimental & Clinical Cancer Research, 2022 - Springer
Cancer immunotherapy has emerged as a novel cancer treatment, although recent
immunotherapy trials have produced suboptimal outcomes, with durable responses seen …

Cell membrane coating integrity affects the internalization mechanism of biomimetic nanoparticles

L Liu, X Bai, MV Martikainen, A Kårlund… - Nature …, 2021 - nature.com
Cell membrane coated nanoparticles (NPs) have recently been recognized as attractive
nanomedical tools because of their unique properties such as immune escape, long blood …

Cancer cell-mitochondria hybrid membrane coated Gboxin loaded nanomedicines for glioblastoma treatment

Y Zou, Y Sun, Y Wang, D Zhang, H Yang… - Nature …, 2023 - nature.com
Glioblastoma (GBM) remains the most lethal malignant tumours. Gboxin, an oxidative
phosphorylation inhibitor, specifically restrains GBM growth by inhibiting the activity of F0F1 …

Role of exosomal non-coding RNAs from tumor cells and tumor-associated macrophages in the tumor microenvironment

Z Xu, Y Chen, L Ma, Y Chen, J Liu, Y Guo, T Yu… - Molecular Therapy, 2022 - cell.com
Exosomes have a crucial role in intercellular communication and mediate interactions
between tumor cells and tumor-associated macrophages (TAMs). Exosome-encapsulated …

A modular approach to enhancing cell membrane-coated nanoparticle functionality using genetic engineering

N Krishnan, Y Jiang, J Zhou, A Mohapatra… - Nature …, 2024 - nature.com
Since their initial development, cell membrane-coated nanoparticles (CNPs) have become
increasingly popular in the biomedical field. Despite their inherent versatility and ability to …

(Nano) platforms in breast cancer therapy: drug/gene delivery, advanced nanocarriers and immunotherapy

M Ashrafizadeh, A Zarrabi, A Bigham… - Medicinal Research …, 2023 - Wiley Online Library
Breast cancer is the most malignant tumor in women, and there is no absolute cure for it.
Although treatment modalities including surgery, chemotherapy, and radiotherapy are …

Macrophage cell membrane-based nanoparticles: a new promising biomimetic platform for targeted delivery and treatment

Y Wu, S Wan, S Yang, H Hu, C Zhang, J Lai… - Journal of …, 2022 - Springer
Synthetic nanoparticles with surface bioconjugation are promising platforms for targeted
therapy, but their simple biological functionalization is still a challenging task against the …

Boosting checkpoint immunotherapy with biomaterials

L Liu, Y Pan, C Zhao, P Huang, X Chen, L Rao - ACS nano, 2023 - ACS Publications
The immune checkpoint blockade (ICB) therapy has revolutionized the field of cancer
treatment, while low response rates and systemic toxicity limit its clinical outcomes. With the …

A polymer multicellular nanoengager for synergistic NIR‐II photothermal immunotherapy

C Xu, Y Jiang, Y Han, K Pu, R Zhang - Advanced Materials, 2021 - Wiley Online Library
Cell‐membrane‐coated nanoparticles (CCNPs) that integrate the biophysiological
advantages of cell membranes with the multifunctionalities of synthetic materials hold great …