Next-generation sequencing (NGS) technology has expanded in the last decades with
significant improvements in the reliability, sequencing chemistry, pipeline analyses, data …

Neoplasms change over time through a process of cell-level evolution, driven by genetic
and epigenetic alterations. However, the ecology of the microenvironment of a neoplastic …

High-throughput amplicon sequencing of large genomic regions remains challenging for
short-read technologies. Here, we report a high-throughput amplicon sequencing approach …

Intra-tumor heterogeneity (ITH) is a mechanism of therapeutic resistance and therefore an
important clinical challenge. However, the extent, origin, and drivers of ITH across cancer …

Cancers are composed of populations of cells with distinct molecular and phenotypic
features, a phenomenon termed intratumor heterogeneity (ITH). ITH in lung cancers has not …

Myelodysplastic syndromes (MDS) are a heterogeneous group of chronic hematological
malignancies characterized by dysplasia, ineffective hematopoiesis and a variable risk of …

Intratumor heterogeneity has been widely reported in human cancers, but our knowledge of
how this genetic diversity emerges over time remains limited. A central challenge in studying …

The extent of heterogeneity among driver gene mutations present in naturally occurring
metastases—that is, treatment-naive metastatic disease—is largely unknown. To address …

Background Intratumor heterogeneity may foster tumor evolution and adaptation and hinder
personalized-medicine strategies that depend on results from single tumor-biopsy samples …

Melanoma is a cancer that exhibits one of the most aggressive and heterogeneous features.
The incidence rate escalates. A high number of clones harboring various mutations …