The past decade has witnessed a rapid growth in understanding of the pivotal roles of
mechanical stresses and physical forces in cell biology. As a result, an integrated view of …

Biological tissues are composed of various cell types working cooperatively to perform their
respective function within organs and the whole body. During development, embryogenesis …

Activity and autonomous motion are fundamental in living and engineering systems. This
has stimulated the new field of'active matter'in recent years, which focuses on the physical …

Actomyosin machinery endows cells with contractility at a single-cell level. However, within a
monolayer, cells can be contractile or extensile based on the direction of pushing or pulling …

Tissues acquire function and shape via differentiation and morphogenesis. Both processes
are driven by coordinating cellular forces and shapes at the tissue scale, but general …

Eukaryotic cells in living tissues form dynamic patterns with spatially varying orientational
order that affects important physiological processes such as apoptosis and cell migration …

During vertebrate embryogenesis, cell collectives engage in coordinated behavior to form
tissue structures of increasing complexity. In the avian skin, assembly into follicles depends …

Epithelial cells rapidly adapt their behaviour in response to increasing tissue demands.
However, the processes that finely control these cell decisions remain largely unknown. The …

Background and Aims Acute liver damage causes hepatocyte stress and death, but in
chronic liver disease impaired hepatocyte regeneration and immune cell infiltration prevents …

To initiate directed movement, cells must become polarized, establishing a protrusive
leading edge and a contractile trailing edge. This symmetry-breaking process involves …