Melatonin production is highly conserved in nature through different species including
bacteria, unicellular eukaryotes, algae, plants invertebrates, and vertebrates (Hardeland et …

CYP11A1, found only in vertebrates, catalyzes the first step of steroidogenesis where
cholesterol is converted to pregnenolone. The purified enzyme, also converts desmosterol …

Glucocorticoid synthesis is a complex, multistep process that starts with cholesterol being
delivered to the inner membrane of mitochondria by StAR and StAR-related proteins. Here …

To investigate whether novel pathways of vitamin D3 (D3) and 7-dehydrocholesterol (7DHC)
metabolism initiated by CYP11A1 and previously characterized in vitro, occur in vivo, we …

Edible mushrooms are popular functional foods attributed to their rich nutritional bioactive
constituent profile influencing cardiovascular function. Edible mushrooms are omnipresent …

CYP11A1, a member of the cytochrome P450 family, plays several key roles in the human
body. It catalyzes the first and rate-limiting step in steroidogenesis, converting cholesterol to …

The mammalian skin is a heterogeneous organ/tissue covering our body, showing regional
variations and endowed with neuroendocrine activities. The latter is represented by its ability …

Vitamin D is the sunshine vitamin. During exposure to sunlight, 7-dehydrocholesterol in the
skin absorbs ultraviolet B (UVB) radiation converting it to previtamin D3. Previtamin D3 …

Current understanding of vitamin D tends to be focussed on the measurement of the major
circulating form 25‐hydroxyvitamin D3 (25OHD3) and its conversion to the active hormonal …

The classical pathway of vitamin D activation follows the sequence D3→ 25 (OH) D3→ 1, 25
(OH) 2 D3 with the final product acting on the receptor for vitamin D (VDR). An alternative …