Protein evolution or engineering studies are traditionally focused on amino acid
substitutions and the way these contribute to fitness. Meanwhile, the insertion and deletion …

Enzymatic deconstruction of poly (ethylene terephthalate)(PET) is under intense
investigation, given the ability of hydrolase enzymes to depolymerize PET to its constituent …

Enzymes have been shaped by evolution over billions of years to catalyse the chemical
reactions that support life on earth. Dispersed in the literature, or organised in online …

Perturbation of soil microbial communities by rising temperatures could have important
consequences for biodiversity and future climate, particularly in tropical forests where high …

Abstract Machine learning could enable an unprecedented level of control in protein
engineering for therapeutic and industrial applications. Critical to its use in designing …

Protein stability and evolvability influence each other. Although protein dynamics play
essential roles in various catalytically important properties, their high flexibility and diversity …

The sequence-structure-function paradigm has dominated twentieth century molecular
biology. The paradigm tacitly stipulated that for each sequence there exists a single, well …

Decades of structure-function studies have established our current extensive understanding
of enzymes. However, traditional structural models are snapshots of broader conformational …

The persistent low temperature that characterize polar habitats combined with the
requirement for light for all photoautotrophs creates a conundrum. The absorption of too …

Realizing efficient carbon capture by high-performance CO 2 separation membrane is
significant to mitigate the increasing emissions of greenhouse gas CO 2. Inspired by the …