The yeast cell wall is a strong, but elastic, structure that is essential not only for the
maintenance of cell shape and integrity, but also for progression through the cell cycle …

Among the myriad of intracellular signaling networks that govern the cardiac development
and pathogenesis, mitogen-activated protein kinases (MAPKs) are prominent players that …

An appropriate response and adaptation to hyperosmolarity, ie., an external osmolarity that
is higher than the physiological range, can be a matter of life or death for all cells. It is …

Signaling pathways that activate different mitogen-activated protein kinases (MAPKs) elicit
many of the responses that are evoked in cells by changes in certain environmental …

Protein structure and function can be altered by reactive oxygen species produced either by
cell metabolism or by external oxidants. Although catalases, superoxide dismutases and …

Mitogen-activated protein (MAP) kinases belong to a highly conserved family of Ser-Thr
protein kinases in the human kinome and have diverse roles in broad physiological …

The MAP kinases, discovered approximately 20 years ago, together with their immediate
upstream regulators, are among the most highly studied signal transduction molecules. This …

Mitogen-activated protein kinase (MAPK) cascades and the calcium–calcineurin pathway
control fundamental aspects of fungal growth, development and reproduction. Core …

Owing to their crucial roles in regulating protein function, phosphorylation sites
(phosphosites) are expected to be evolutionarily conserved. However, mixed results …

Two mitogen‐activated protein kinase (MAPK) pathways, viz. the high‐osmolarity glycerol
(HOG) and the cell wall integrity (CWI) pathways, regulate stress responses in the yeast …