Cryo-electron microscopy in the study of virus entry and infection
Viruses have been responsible for many epidemics and pandemics that have impacted
human life globally. The COVID-19 pandemic highlighted both our vulnerability to viral …
human life globally. The COVID-19 pandemic highlighted both our vulnerability to viral …
Antibody Data Analysis from Diverse Immune Libraries
AS Fahad, MF Gutiérrez-Gonzalez… - Cold Spring Harbor …, 2024 - cshprotocols.cshlp.org
Antibody functional screening studies and next-generation sequencing require careful
processing and interpretation of sequence data for optimal results. Here, we provide a …
processing and interpretation of sequence data for optimal results. Here, we provide a …
Vaccine-elicited and naturally elicited antibodies differ in their recognition of the HIV-1 fusion peptide
Broadly neutralizing antibodies have been proposed as templates for HIV-1 vaccine design,
but it has been unclear how similar vaccine-elicited antibodies are to their naturally elicited …
but it has been unclear how similar vaccine-elicited antibodies are to their naturally elicited …
Beyond Single Clones: High-Throughput Sequencing in Antibody Discovery
AS Fahad, MF Gutiérrez-Gonzalez… - Cold Spring Harbor …, 2024 - cshprotocols.cshlp.org
Antibody repertoire sequencing and display library screening are powerful approaches for
antibody discovery and engineering that can connect DNA sequence with antibody function …
antibody discovery and engineering that can connect DNA sequence with antibody function …
A library-on-library screen reveals the breadth expansion landscape of a broadly neutralizing betacoronavirus antibody
Broadly neutralizing antibodies (bnAbs) typically evolve cross-reactivity breadth through
acquiring somatic hypermutations. While evolution of breadth requires improvement of …
acquiring somatic hypermutations. While evolution of breadth requires improvement of …