Abstract Properties of responsible for biological activity tetrazoles are considered. Examples
are given of active pharmaceutical ingredients of modern drugs containing the tetrazole ring …

Quinolones are considered as a big family of multi-faceted drugs; their chemical synthesis is
flexible and can be easily adapted to prepare new congeners with rationally devised …

Finding new isofunctional chemotypes with the aim of identifying new lead candidates
remains a challenging task in medicinal chemistry. Different virtual screening techniques …

Influenza virus (IFV) causes periodic global influenza pandemics, resulting in substantial
socioeconomic loss and burden on medical facilities. Yearly variation in the effectiveness of …

Abstract HIV‐1 integrase (IN) catalyzes the integration of proviral DNA into the host genome,
an essential step for viral replication. Inhibition of IN catalytic activity provides an attractive …

HIV-1 integrase is an essential enzyme for viral replication and a validated target for the
development of drugs against AIDS. With an aim to discover new potent inhibitors of HIV-1 …

Abstract Context The 2, 4-dioxo-4-phenylbutanoic acid (DPBA) is a subject of interest in
pharmaceutical research, particularly in developing new drugs targeting viral and bacterial …

Resistance selection by human immunodeficiency virus (HIV) toward known drug regimens
necessitates the discovery of structurally novel antivirals with a distinct resistance profile. On …

HIV-1 integrase (IN) has been validated as an attractive target for the treatment of HIV/AIDS.
Several studies have confirmed that the metal binding function is a crucial feature in many of …

Integrase (IN) represents a clinically validated target for the development of antivirals
against human immunodeficiency virus (HIV). Inhibitors with a novel structure core are …