Bone is a dynamic organ maintained by tightly regulated mechanisms. With old age, bone
homeostasis, which is maintained by an intricate balance between bone formation and bone …

Bone metastases are characterized by increased osteoblastic and/or osteolytic processes
depending on the tumor type. The altogether destructive effect of metastasis formation …

Laparoscopic Roux‐en‐Y gastric bypass (RYGB) and sleeve gastrectomy (SG) are common
and effective methods to treat severe obesity, but these procedures can adversely influence …

Transiliac bone biopsies, while widely considered to be the standard for the analysis of bone
microstructure, are typically restricted to specialized centers. The benefit of Trabecular Bone …

Background Mice are increasingly used in fracture healing research because of the
opportunity to use transgenic animals. While both, male and female mice are employed …

Context: The role of sclerostin as a key regulator of bone formation remains unknown after
Roux-en-Y gastric bypass (RYGB) or laparoscopic sleeve gastrectomy (SG). Objectives: The …

Wnt signaling is critically involved in fracture healing. Existing data predominantly relies on
rodent models. Here, we explored local and circulating Dickkopf-1 (DKK1) levels in patients …

Background Wnt-catenin signaling antagonists sclerostin and dickkopf-related protein-1
(Dkk-1) inhibit bone formation and are involved in the pathogenesis of postmenopausal …

Patients with ankylosing spondylitis (AS) have an increased risk of bone loss and vertebral
fractures. In this study, we explored the hypothesis that the excess bone loss and vertebral …

Bone turnover markers (BTMs) derived from the secretory activities of osteoblasts and the
matrix-degrading activities of osteoclasts are useful in monitoring the progression of …