Targeting RAGE signaling in inflammatory disease
BI Hudson, ME Lippman - Annual review of medicine, 2018 - annualreviews.org
The receptor for advanced glycation end-products (RAGE) is a multiligand pattern
recognition receptor implicated in diverse chronic inflammatory states. RAGE binds and …
recognition receptor implicated in diverse chronic inflammatory states. RAGE binds and …
Mechanisms of diabetic complications
It is increasingly apparent that not only is a cure for the current worldwide diabetes epidemic
required, but also for its major complications, affecting both small and large blood vessels …
required, but also for its major complications, affecting both small and large blood vessels …
A multimodal RAGE-specific inhibitor reduces amyloid β–mediated brain disorder in a mouse model of Alzheimer disease
R Deane, I Singh, AP Sagare, RD Bell… - The Journal of …, 2012 - Am Soc Clin Investig
In Alzheimer disease (AD), amyloid β peptide (Aβ) accumulates in plaques in the brain.
Receptor for advanced glycation end products (RAGE) mediates Aβ-induced perturbations …
Receptor for advanced glycation end products (RAGE) mediates Aβ-induced perturbations …
RAGE regulation and signaling in inflammation and beyond
K Kierdorf, G Fritz - Journal of leukocyte biology, 2013 - academic.oup.com
ABSTRACT RAGE is a key molecule in the onset and sustainment of the inflammatory
response. New studies indicate that RAGE might represent a new link between the innate …
response. New studies indicate that RAGE might represent a new link between the innate …
All the “RAGE” in lung disease: The receptor for advanced glycation endproducts (RAGE) is a major mediator of pulmonary inflammatory responses
EA Oczypok, TN Perkins, TD Oury - Paediatric respiratory reviews, 2017 - Elsevier
The receptor for advanced glycation endproducts (RAGE) is a pro-inflammatory pattern
recognition receptor (PRR) that has been implicated in the pathogenesis of numerous …
recognition receptor (PRR) that has been implicated in the pathogenesis of numerous …
RAGE (Receptor for Advanced Glycation Endproducts), RAGE ligands, and their role in cancer and inflammation
Abstract The Receptor for Advanced Glycation Endproducts [RAGE] is an evolutionarily
recent member of the immunoglobulin super-family, encoded in the Class III region of the …
recent member of the immunoglobulin super-family, encoded in the Class III region of the …
Advanced glycation end products (AGEs) and chronic kidney disease: does the modern diet AGE the kidney?
Since the 1980s, chronic kidney disease (CKD) affecting all ages has increased by almost
25%. This increase may be partially attributable to lifestyle changes and increased global …
25%. This increase may be partially attributable to lifestyle changes and increased global …
The receptor for advanced glycation end-products (RAGE) is an important pattern recognition receptor (PRR) for inflammaging
T Teissier, É Boulanger - Biogerontology, 2019 - Springer
The receptor for advanced glycation end-products (RAGE) was initially characterized and
named for its ability to bind to advanced glycation end-products (AGEs) that form upon the …
named for its ability to bind to advanced glycation end-products (AGEs) that form upon the …
Multiple levels of regulation determine the role of the receptor for AGE (RAGE) as common soil in inflammation, immune responses and diabetes mellitus and its …
A Bierhaus, PP Nawroth - Diabetologia, 2009 - Springer
The pattern recognition receptor or receptor for AGE (RAGE) is constitutionally expressed in
a few cell types only. However in almost all cells studied so far it is induced by reactions …
a few cell types only. However in almost all cells studied so far it is induced by reactions …
The AGE-RAGE axis: implications for age-associated arterial diseases
LM Senatus, AM Schmidt - Frontiers in genetics, 2017 - frontiersin.org
The process of advanced glycation leads to the generation and accumulation of an
heterogeneous class of molecules called advanced glycation endproducts, or AGEs. AGEs …
heterogeneous class of molecules called advanced glycation endproducts, or AGEs. AGEs …