Cancer accounts for numerous deaths each year, and it is one of the most common causes
of death worldwide, despite many breakthroughs in the discovery of novel anticancer …

Lung cancer is the leading cause of death in men and women worldwide, affecting millions
of people. Between the two types of lung cancers, non-small cell lung cancer (NSCLC) is …

Microtubules are cylindrical protein polymers formed from α β-tubulin heterodimers in the
cytoplasm of eukaryotic cells. Microtubule disturbance may cause cell cycle arrest in the …

Two series of indole derivatives 4–17, 20–22 were easily prepared and assayed for their
radical-scavenging ability. Arylidene-1H-indole-2-carbohydrazones showed different extent …

Paclitaxel is one of the most commonly used drugs for the treatment of nonsmall cell lung
cancer (NSCLC). However acquired resistance to paclitaxel, epithelial to mesenchymal …

In recent years, indole-indazolyl hydrazide-hydrazone derivatives with strong cell growth
inhibition and apoptosis induction characteristics are being strongly screened for their …

Background Liver cancer is predicted to be the sixth most diagnosed cancer globally and
fourth leading cause of cancer deaths. In this study, a series of indole-3-isoxazole-5 …

Abstract Structurally diverse indole-3-pyrazole-5-carboxamide analogues (10-29) were
designed, synthesized, and evaluated for their antiproliferative activity against three cancer …

Tubulin inhibitors can interfere with normal cell mitosis and inhibit cell proliferation through
interfering with the normal structure and function of microtubules, forming spindle filaments …

Plant viral diseases cause tremendous decreases in crop yield and quality. Natural products
have always been a valuable source for lead discovery in medicinal and agricultural …