PPARγ signaling in hepatocarcinogenesis: mechanistic insights for cellular reprogramming and therapeutic implications
SM Ishtiaq, MI Arshad, JA Khan - Pharmacology & Therapeutics, 2022 - Elsevier
Liver cancer or hepatocellular carcinoma (HCC) is leading cause of cancer-related
mortalities globally. The therapeutic approaches for chronic liver diseases-associated liver …
mortalities globally. The therapeutic approaches for chronic liver diseases-associated liver …
[HTML][HTML] Hepatoprotective and anti-fibrotic agents: It's time to take the next step
R Weiskirchen - Frontiers in pharmacology, 2016 - frontiersin.org
Hepatic fibrosis and cirrhosis cause strong human suffering and necessitate a monetary
burden worldwide. Therefore, there is an urgent need for the development of therapies. Pre …
burden worldwide. Therefore, there is an urgent need for the development of therapies. Pre …
[HTML][HTML] Activation of PPARγ/P53 signaling is required for curcumin to induce hepatic stellate cell senescence
H Jin, N Lian, F Zhang, L Chen, Q Chen, C Lu… - Cell death & …, 2016 - nature.com
Activation of quiescent hepatic stellate cells (HSCs) is the major event in hepatic
fibrogenesis, along with enhancement of cell proliferation and overproduction of …
fibrogenesis, along with enhancement of cell proliferation and overproduction of …
micro RNA‐122 regulates hypoxia‐inducible factor‐1 and vimentin in hepatocytes and correlates with fibrosis in diet‐induced steatohepatitis
T Csak, S Bala, D Lippai, A Satishchandran… - Liver …, 2015 - Wiley Online Library
Background & Aims miR‐122 is the most abundant mi RNA in the liver particularly in
hepatocytes where it targets cholesterol metabolism. Steatosis, a key component of non …
hepatocytes where it targets cholesterol metabolism. Steatosis, a key component of non …
[HTML][HTML] Transplanted human amniotic membrane-derived mesenchymal stem cells ameliorate carbon tetrachloride-induced liver cirrhosis in mouse
DG Zhang, MY Jiang, DS Miao - PloS one, 2011 - journals.plos.org
Background Human amniotic membrane-derived mesenchymal stem cells (hAMCs) have
the potential to reduce heart and lung fibrosis, but whether could reduce liver fibrosis …
the potential to reduce heart and lung fibrosis, but whether could reduce liver fibrosis …
[HTML][HTML] Therapeutic inhibition of miR-155 attenuates liver fibrosis via STAT3 signaling
Most chronic liver diseases progress to liver fibrosis, which, when left untreated, can lead to
cirrhosis and hepatocellular carcinoma. MicroRNA (miRNA)-targeted therapeutics have …
cirrhosis and hepatocellular carcinoma. MicroRNA (miRNA)-targeted therapeutics have …
[HTML][HTML] Ascorbate is a primary antioxidant in mammals
J Fujii, T Osaki, T Bo - Molecules, 2022 - mdpi.com
Ascorbate (vitamin C in primates) functions as a cofactor for a number of enzymatic reactions
represented by prolyl hydroxylases and as an antioxidant due to its ability to donate …
represented by prolyl hydroxylases and as an antioxidant due to its ability to donate …
[HTML][HTML] Potent effects of dioscin against liver fibrosis
X Zhang, X Han, L Yin, L Xu, Y Qi, Y Xu, H Sun, Y Lin… - Scientific reports, 2015 - nature.com
We previously reported the promising effects of dioscin against liver injury, but its effect on
liver fibrosis remains unknown. The present work investigated the activities of dioscin …
liver fibrosis remains unknown. The present work investigated the activities of dioscin …
The agonists of peroxisome proliferator-activated receptor-γ for liver fibrosis
J Li, C Guo, J Wu - Drug Design, Development and Therapy, 2021 - Taylor & Francis
Liver fibrosis is a common link in the transformation of acute and chronic liver diseases to
cirrhosis. It is of great clinical significance to study the factors associated with the induction of …
cirrhosis. It is of great clinical significance to study the factors associated with the induction of …
[HTML][HTML] Nutrition and cellular senescence in obesity-related disorders
T Rubio-Tomás, A Rueda-Robles, J Plaza-Díaz… - The Journal of …, 2022 - Elsevier
Adequate nutrition is vital for immune homeostasis. However, the incidence of obesity is
increasing worldwide due to the adoption of the Western diet and a sedentary lifestyle …
increasing worldwide due to the adoption of the Western diet and a sedentary lifestyle …