Decoding Connectivity Map-based drug repurposing for oncotherapy
Y Zhao, X Chen, J Chen, X Qi - Briefings in Bioinformatics, 2023 - academic.oup.com
The rising global burden of cancer has driven considerable efforts into the research and
development of effective anti-cancer agents. Fortunately, with impressive advances in …
development of effective anti-cancer agents. Fortunately, with impressive advances in …
Early diagnosis and screening for lung cancer
H Kadara, LM Tran, B Liu… - Cold Spring …, 2021 - perspectivesinmedicine.cshlp.org
Cancer interception refers to actively blocking the cancer development process by
preventing progression of premalignancy to invasive disease. The rate-limiting steps for …
preventing progression of premalignancy to invasive disease. The rate-limiting steps for …
Quantitative phosphoproteomic analyses identify STK11IP as a lysosome-specific substrate of mTORC1 that regulates lysosomal acidification
The evolutionarily conserved serine/threonine kinase mTORC1 is a central regulator of cell
growth and proliferation. mTORC1 is activated on the lysosome surface. However, once …
growth and proliferation. mTORC1 is activated on the lysosome surface. However, once …
Posttranslationally Acting Arginases Provide a Ribosomal Route to Non‐proteinogenic Ornithine Residues in Diverse Peptide Sequences
S Mordhorst, BI Morinaka, AL Vagstad… - Angewandte …, 2020 - Wiley Online Library
Ornithine is a component of many bioactive nonribosomal peptides but is challenging to
incorporate into ribosomal products. We recently identified OspR, a cyanobacterial arginase …
incorporate into ribosomal products. We recently identified OspR, a cyanobacterial arginase …
Structural and Biochemical Insights into Post-Translational Arginine-to-Ornithine Peptide Modifications by an Atypical Arginase
S Mordhorst, T Badmann, NM Bösch… - ACS Chemical …, 2023 - ACS Publications
Landornamide A is a ribosomally synthesized and post-translationally modified peptide
(RiPP) natural product with antiviral activity. Its biosynthetic gene cluster encodes─ among …
(RiPP) natural product with antiviral activity. Its biosynthetic gene cluster encodes─ among …
[HTML][HTML] Extreme-Phenotype Genome-Wide Association Analysis for Growth Traits in Spotted Sea Bass (Lateolabrax maculatus) Using Whole-Genome …
Z Zhou, G Shao, Y Shen, F He, X Tu, J Ji, J Ao, X Chen - Animals, 2024 - mdpi.com
Simple Summary Fish farming provides an efficient means of obtaining high-quality protein
for humans. However, the decreased growth rate of aquaculture fish due to germplasm …
for humans. However, the decreased growth rate of aquaculture fish due to germplasm …
Induced Degradation of Lineage-specific Oncoproteins Drives the Selective PARP1 Inhibitor Toxicity in Small Cell Lung Cancer
A subset of small cell lung cancer (SCLC) shows clinically relevant response to PARP1
inhibitors (PARPi). However, BRCA1/2 mutations are not commonly found in SCLC, and the …
inhibitors (PARPi). However, BRCA1/2 mutations are not commonly found in SCLC, and the …
Hydroxylation of Actin Impairs Cell Motility Through Blocking its' Histidine Methylation
Protein hydroxylation is a post translational modification happens on various amino acids,
which is catalyzed by the oxoglutarate and oxygen dependent dioxygenases. The best …
which is catalyzed by the oxoglutarate and oxygen dependent dioxygenases. The best …