Metabolic host responses to infection by intracellular bacterial pathogens

W Eisenreich, J Heesemann, T Rudel… - Frontiers in cellular and …, 2013 - frontiersin.org
The interaction of bacterial pathogens with mammalian hosts leads to a variety of
physiological responses of the interacting partners aimed at an adaptation to the new …

Mass spectrometry-based proteomic approaches to study pathogenic bacteria-host interactions

Y Yang, M Hu, K Yu, X Zeng, X Liu - Protein & cell, 2015 - academic.oup.com
Elucidation of molecular mechanisms underlying host-pathogen interactions is important for
control and treatment of infectious diseases worldwide. Within the last decade, mass …

Parallel Exploitation of Diverse Host Nutrients Enhances Salmonella Virulence

B Steeb, B Claudi, NA Burton, P Tienz, A Schmidt… - PLoS …, 2013 - journals.plos.org
Pathogen access to host nutrients in infected tissues is fundamental for pathogen growth
and virulence, disease progression, and infection control. However, our understanding of …

Model‐driven multi‐omic data analysis elucidates metabolic immunomodulators of macrophage activation

A Bordbar, ML Mo, ES Nakayasu… - Molecular systems …, 2012 - embopress.org
Macrophages are central players in immune response, manifesting divergent phenotypes to
control inflammation and innate immunity through release of cytokines and other signaling …

[HTML][HTML] Thymol disrupts the membrane integrity of Salmonella ser. typhimurium in vitro and recovers infected macrophages from oxidative stress in an ex vivo model

AK Chauhan, SC Kang - Research in microbiology, 2014 - Elsevier
Salmonella is a common bacterial enteropathogen responsible for many deaths every year.
In the present study, we evaluated the mechanism of action of thymol against Salmonella …

Reprogramming of macrophages employing gene regulatory and metabolic network models

F Hörhold, D Eisel, M Oswald, A Kolte… - PLoS computational …, 2020 - journals.plos.org
Upon exposure to different stimuli, resting macrophages undergo classical or alternative
polarization into distinct phenotypes that can cause fatal dysfunction in a large range of …

Metabolic adaptations of intracellullar bacterial pathogens and their mammalian host cells during infection (“pathometabolism”)

W Eisenreich, J Heesemann, T Rudel… - Metabolism and …, 2015 - Wiley Online Library
Metabolic adaptation reactions are common when prokaryotes interact with eukaryotic cells,
especially when the bacteria are internalized by these host cells. Such adaptations lead to …

Spatiotemporal proteomics uncovers cathepsin-dependent macrophage cell death during Salmonella infection

J Selkrig, N Li, A Hausmann, MSJ Mangan… - Nature …, 2020 - nature.com
The interplay between host and pathogen relies heavily on rapid protein synthesis and
accurate protein targeting to ensure pathogen destruction. To gain insight into this dynamic …

Foodomics and food safety: Where we are

U Andjelković, M Šrajer Gajdošik… - Food Technology and …, 2017 - hrcak.srce.hr
Sažetak The power of foodomics as a discipline that is now broadly used for quality
assurance of food products and adulteration identification, as well as for determining the …

Impact of Salmonella Infection on Host Hormone Metabolism Revealed by Metabolomics

LCM Antunes, ET Arena, A Menendez, J Han… - Infection and …, 2011 - Am Soc Microbiol
The interplay between pathogens and their hosts has been studied for decades using
targeted approaches, such as the analysis of mutants and host immunological responses …