PH (pleckstrin homology) domains represent the 11th most common domain in the human
proteome. They are best known for their ability to bind phosphoinositides with high affinity …

Spliceosomal small nuclear ribonucleoproteins (snRNPs) are essential components of the
nuclear pre-mRNA processing machinery. A hallmark of these particles is a ring-shaped …

PRMT5 is an essential arginine methyltransferase and a therapeutic target in MTAP-null
cancers. PRMT5 uses adaptor proteins for substrate recruitment through a previously …

For each round of pre-mRNA splicing, a spliceosome is assembled anew on its substrate.
RNA–protein remodeling events required for spliceosome assembly, splicing catalysis, and …

Small nuclear ribonucleoproteins (snRNPs) represent key constituents of major and minor
spliceosomes. snRNPs contain a common core, composed of seven Sm proteins bound to …

pICln is an essential, highly conserved 26-kDa protein whose functions include binding to
Sm proteins in the cytoplasm of human cells and mediating the ordered and regulated …

To assess the potential of intrinsically disordered proteins (IDPs) as drug design targets, we
have analyzed the ligand‐binding cavities of two datasets of IDPs (containing 37 and 16 …

O-GlcNAcylation is a post-translational modification of proteins that controls a variety of
cellular processes, is chronically elevated in diabetes mellitus, and may contribute to the …

The biogenesis of small uridine-rich nuclear ribonucleoproteins (UsnRNPs) depends on the
methylation of Sm proteins catalyzed by the methylosome and the subsequent action of the …

The ultimate goal of bioinformatics or computational chemical biology is the sequence-
based prediction of protein functionality. However, due to the degeneracy of the primary …