Since the discovery of the major excitatory and inhibitory neurotransmitters and their
receptors in the brain, many have deliberated over their likely structures and how these may …

Glycine receptors (GlyRs) are pentameric,'Cys-loop'receptors that form chloride-permeable
channels and mediate fast inhibitory signalling throughout the central nervous system,. In …

Defining the sites of action of ethanol on brain proteins is a major prerequisite to
understanding the molecular pharmacology of this drug. The main barrier to reaching an …

Autism spectrum disorder (ASD) is a common neurodevelopmental condition characterized
by marked genetic heterogeneity. Recent studies of rare structural and sequence variants …

The epithelial Na+ channel (ENaC) functions as a pathway for Na+ absorption in the kidney
and lung, where it is crucial for Na+ homeostasis and blood pressure regulation. However …

Human hyperekplexia is a neuromotor disorder caused by disturbances in inhibitory glycine‐
mediated neurotransmission. Mutations in genes encoding for glycine receptor subunits or …

Pentameric ligand-gated ion channels are targets of general anesthetics. Although the
search for discrete anesthetic binding sites has achieved some degree of success, little is …

Persistent pain remains a tremendous health problem due to both its prevalence and dearth
of effective therapeutic interventions. To maximize pain relief while minimizing side effects …

Pentameric ligand gated ion channels (pLGICs) are crucial in electrochemical signaling but
exact molecular mechanisms of their activation remain elusive. So far, major effort focused …

Herein, we identify the coordination environment of Cu 2+ in the human α1-glycine receptor
(GlyR). GlyRs are members of the pentameric ligand-gated ion channel superfamily (pLGIC) …