Obesity I: Overview and molecular and biochemical mechanisms
Obesity is a chronic, relapsing condition characterized by excess body fat. Its prevalence
has increased globally since the 1970s, and the number of obese and overweight people is …
has increased globally since the 1970s, and the number of obese and overweight people is …
Metabolic regulation of kisspeptin—the link between energy balance and reproduction
VM Navarro - Nature reviews endocrinology, 2020 - nature.com
Hypothalamic kisspeptin neurons serve as the nodal regulatory centre of reproductive
function. These neurons are subjected to a plethora of regulatory factors that ultimately affect …
function. These neurons are subjected to a plethora of regulatory factors that ultimately affect …
Clinical practice guideline for the evaluation and treatment of children and adolescents with obesity
SE Hampl, SG Hassink, AC Skinner, SC Armstrong… - …, 2023 - publications.aap.org
The current and long-term health of 14.4 million children and adolescents is affected by
obesity, 1, 2 making it one of the most common pediatric chronic diseases. 3–5 Long …
obesity, 1, 2 making it one of the most common pediatric chronic diseases. 3–5 Long …
[HTML][HTML] Effects of maternal obesity on placental function and fetal development
Obesity has reached epidemic proportions and pregnancies in obese mothers have
increased risk for complications including gestational diabetes, hypertensive disorders …
increased risk for complications including gestational diabetes, hypertensive disorders …
Age-related consequences of childhood obesity
The severity and frequency of childhood obesity has increased significantly over the past
three to four decades. The health effects of increased body mass index as a child may …
three to four decades. The health effects of increased body mass index as a child may …
Maternal obesity and neurodevelopmental and psychiatric disorders in offspring
AG Edlow - Prenatal diagnosis, 2017 - Wiley Online Library
There is a growing body of evidence from both human epidemiologic and animal studies
that prenatal and lactational exposure to maternal obesity and high‐fat diet are associated …
that prenatal and lactational exposure to maternal obesity and high‐fat diet are associated …
Metabolism and the circadian clock converge
K Eckel-Mahan, P Sassone-Corsi - Physiological reviews, 2013 - journals.physiology.org
Circadian rhythms occur in almost all species and control vital aspects of our physiology,
from sleeping and waking to neurotransmitter secretion and cellular metabolism …
from sleeping and waking to neurotransmitter secretion and cellular metabolism …
[HTML][HTML] Fetal programming of the metabolic syndrome
A Marciniak, J Patro-Małysza, Ż Kimber-Trojnar… - Taiwanese Journal of …, 2017 - Elsevier
Prenatal development is currently recognized as a critical period in the etiology of human
diseases. This is particularly so when an unfavorable environment interacts with a genetic …
diseases. This is particularly so when an unfavorable environment interacts with a genetic …
High fat diet induced developmental defects in the mouse: oocyte meiotic aneuploidy and fetal growth retardation/brain defects
KM Luzzo, Q Wang, SH Purcell, M Chi, PT Jimenez… - PloS one, 2012 - journals.plos.org
Background Maternal obesity is associated with poor outcomes across the reproductive
spectrum including infertility, increased time to pregnancy, early pregnancy loss, fetal loss …
spectrum including infertility, increased time to pregnancy, early pregnancy loss, fetal loss …
Developmental origins of NAFLD: a womb with a clue
SR Wesolowski, KCE Kasmi, KR Jonscher… - Nature reviews …, 2017 - nature.com
Abstract Changes in the maternal environment leading to an altered intrauterine milieu can
result in subtle insults to the fetus, promoting increased lifetime disease risk and/or disease …
result in subtle insults to the fetus, promoting increased lifetime disease risk and/or disease …