Obesity I: Overview and molecular and biochemical mechanisms

RH Lustig, D Collier, C Kassotis, TA Roepke… - Biochemical …, 2022 - Elsevier
Obesity is a chronic, relapsing condition characterized by excess body fat. Its prevalence
has increased globally since the 1970s, and the number of obese and overweight people is …

Metabolic regulation of kisspeptin—the link between energy balance and reproduction

VM Navarro - Nature reviews endocrinology, 2020 - nature.com
Hypothalamic kisspeptin neurons serve as the nodal regulatory centre of reproductive
function. These neurons are subjected to a plethora of regulatory factors that ultimately affect …

Clinical practice guideline for the evaluation and treatment of children and adolescents with obesity

SE Hampl, SG Hassink, AC Skinner, SC Armstrong… - …, 2023 - publications.aap.org
The current and long-term health of 14.4 million children and adolescents is affected by
obesity, 1, 2 making it one of the most common pediatric chronic diseases. 3–5 Long …

[HTML][HTML] Effects of maternal obesity on placental function and fetal development

KR Howell, TL Powell - Reproduction (Cambridge, England), 2017 - ncbi.nlm.nih.gov
Obesity has reached epidemic proportions and pregnancies in obese mothers have
increased risk for complications including gestational diabetes, hypertensive disorders …

Age-related consequences of childhood obesity

MM Kelsey, A Zaepfel, P Bjornstad, KJ Nadeau - Gerontology, 2014 - karger.com
The severity and frequency of childhood obesity has increased significantly over the past
three to four decades. The health effects of increased body mass index as a child may …

Maternal obesity and neurodevelopmental and psychiatric disorders in offspring

AG Edlow - Prenatal diagnosis, 2017 - Wiley Online Library
There is a growing body of evidence from both human epidemiologic and animal studies
that prenatal and lactational exposure to maternal obesity and high‐fat diet are associated …

Metabolism and the circadian clock converge

K Eckel-Mahan, P Sassone-Corsi - Physiological reviews, 2013 - journals.physiology.org
Circadian rhythms occur in almost all species and control vital aspects of our physiology,
from sleeping and waking to neurotransmitter secretion and cellular metabolism …

[HTML][HTML] Fetal programming of the metabolic syndrome

A Marciniak, J Patro-Małysza, Ż Kimber-Trojnar… - Taiwanese Journal of …, 2017 - Elsevier
Prenatal development is currently recognized as a critical period in the etiology of human
diseases. This is particularly so when an unfavorable environment interacts with a genetic …

High fat diet induced developmental defects in the mouse: oocyte meiotic aneuploidy and fetal growth retardation/brain defects

KM Luzzo, Q Wang, SH Purcell, M Chi, PT Jimenez… - PloS one, 2012 - journals.plos.org
Background Maternal obesity is associated with poor outcomes across the reproductive
spectrum including infertility, increased time to pregnancy, early pregnancy loss, fetal loss …

Developmental origins of NAFLD: a womb with a clue

SR Wesolowski, KCE Kasmi, KR Jonscher… - Nature reviews …, 2017 - nature.com
Abstract Changes in the maternal environment leading to an altered intrauterine milieu can
result in subtle insults to the fetus, promoting increased lifetime disease risk and/or disease …