Animal models of serotonergic psychedelics
JB Hanks, J González-Maeso - ACS chemical neuroscience, 2013 - ACS Publications
The serotonin 5-HT2A receptor is the major target of psychedelic drugs such as lysergic acid
diethylamide (LSD), mescaline, and psilocybin. Serotonergic psychedelics induce profound …
diethylamide (LSD), mescaline, and psilocybin. Serotonergic psychedelics induce profound …
Dopamine and the interdependency of time perception and reward
Time is a fundamental dimension of our perception of the world and is therefore of critical
importance to the organization of human behavior. A corpus of work—including recent …
importance to the organization of human behavior. A corpus of work—including recent …
A model of interval timing by neural integration
We show that simple assumptions about neural processing lead to a model of interval timing
as a temporal integration process, in which a noisy firing-rate representation of time rises …
as a temporal integration process, in which a noisy firing-rate representation of time rises …
Risk assessment in man and mouse
F Balci, D Freestone… - Proceedings of the …, 2009 - National Acad Sciences
Human and mouse subjects tried to anticipate at which of 2 locations a reward would
appear. On a randomly scheduled fraction of the trials, it appeared with a short latency at …
appear. On a randomly scheduled fraction of the trials, it appeared with a short latency at …
Time representation in reinforcement learning models of the basal ganglia
Reinforcement learning (RL) models have been influential in understanding many aspects
of basal ganglia function, from reward prediction to action selection. Time plays an important …
of basal ganglia function, from reward prediction to action selection. Time plays an important …
Differential effects of amphetamine and haloperidol on temporal reproduction: dopaminergic regulation of attention and clock speed
Healthy volunteers were tested on 7-s and 17-s peak-interval timing procedures following d-
amphetamine (20mg—oral), haloperidol (2mg—oral), and placebo treatments in order to …
amphetamine (20mg—oral), haloperidol (2mg—oral), and placebo treatments in order to …
Double dissociation of dopamine genes and timing in humans
M Wiener, FW Lohoff, HB Coslett - Journal of cognitive neuroscience, 2011 - direct.mit.edu
A number of lines of evidence implicate dopamine in timing [Rammsayer, TH
Neuropharmacological approaches to human timing. In S. Grondin (Ed.), Psychology of time …
Neuropharmacological approaches to human timing. In S. Grondin (Ed.), Psychology of time …
Premature responses in the five-choice serial reaction time task reflect rodents' temporal strategies: evidence from no-light and pharmacological challenges
ZA Cope, AL Halberstadt, J van Enkhuizen… - …, 2016 - Springer
Rationale The five-choice serial reaction time task (5-CSRTT) is regularly used to study
attention and impulsivity. In the 5-CSRTT, rodents initiate a trial, then after an inter-trial …
attention and impulsivity. In the 5-CSRTT, rodents initiate a trial, then after an inter-trial …
Interval timing accuracy and scalar timing in C57BL/6 mice.
In many species, interval timing behavior is accurate—appropriate estimated durations—
and scalar—errors vary linearly with estimated durations. Whereas accuracy has been …
and scalar—errors vary linearly with estimated durations. Whereas accuracy has been …
Contributions of dopaminergic signaling to timing accuracy and precision
PV Agostino, RK Cheng - Current Opinion in Behavioral Sciences, 2016 - Elsevier
Highlights•Accuracy and precision are important features of interval timing.•DA AGO/ANT
mainly affect interval timing accuracy by altering the clock speed.•Striatal DRD1 or DRD2 …
mainly affect interval timing accuracy by altering the clock speed.•Striatal DRD1 or DRD2 …