Metastatic colorectal cancer: current state and future directions
MG Fakih - Journal of clinical oncology, 2015 - ascopubs.org
Substantial improvements have been made in the management of metastatic colorectal
cancer over the last two decades. The overall survival of patients diagnosed with …
cancer over the last two decades. The overall survival of patients diagnosed with …
Portrait of the PI3K/AKT pathway in colorectal cancer
SA Danielsen, PW Eide, A Nesbakken, T Guren… - … et Biophysica Acta (BBA …, 2015 - Elsevier
Abstract PI3K/AKT signaling leads to reduced apoptosis, stimulates cell growth and
increases proliferation. Under normal conditions, PI3K/AKT activation is tightly controlled …
increases proliferation. Under normal conditions, PI3K/AKT activation is tightly controlled …
Effect of fluorouracil, leucovorin, and oxaliplatin with or without onartuzumab in HER2-negative, MET-positive gastroesophageal adenocarcinoma: the METGastric …
Importance Dysregulation of the mesenchymal-epithelial transition (MET) signaling pathway
is associated with poor prognosis in gastroesophageal adenocarcinoma (GEC). We report …
is associated with poor prognosis in gastroesophageal adenocarcinoma (GEC). We report …
Targeting MET in cancer therapy
HN Mo, P Liu - Chronic diseases and translational medicine, 2017 - mednexus.org
MET encodes a receptor tyrosine kinase c-MET for hepatocyte growth factor (HGF). The
specific combination of c-MET and HGF activates downstream signaling pathways to trigger …
specific combination of c-MET and HGF activates downstream signaling pathways to trigger …
c-MET as a potential therapeutic target and biomarker in cancer
The receptor tyrosine kinase c-MET and its ligand, hepatocyte growth factor (HGF), regulate
multiple cellular processes that stimulate cell proliferation, invasion and angiogenesis. This …
multiple cellular processes that stimulate cell proliferation, invasion and angiogenesis. This …
Hypomethylation of long interspersed nuclear element-1 (LINE-1) leads to activation of proto-oncogenes in human colorectal cancer metastasis
Objective Hypomethylation of LINE-1 elements has emerged as a distinguishing feature in
human cancers. Limited evidence indicates that some LINE-1 elements encode an …
human cancers. Limited evidence indicates that some LINE-1 elements encode an …
Targeting c-MET in gastrointestinal tumours: rationale, opportunities and challenges
CA Bradley, M Salto-Tellez, P Laurent-Puig… - Nature reviews Clinical …, 2017 - nature.com
Data from many preclinical studies, including those using cellular models of colorectal,
gastric, gastro-oesophageal and gastro-oesophageal junction cancers, indicate that the …
gastric, gastro-oesophageal and gastro-oesophageal junction cancers, indicate that the …
Targeting the hepatocyte growth factor–cMET axis in cancer therapy
GR Blumenschein Jr, GB Mills… - Journal of clinical …, 2012 - ascopubs.org
The hepatocyte growth factor (HGF) and its receptor, the transmembrane tyrosine kinase
cMET, promote cell proliferation, survival, motility, and invasion as well as morphogenic …
cMET, promote cell proliferation, survival, motility, and invasion as well as morphogenic …
Inhibition of tumor cell growth, invasion, and metastasis by EXEL-2880 (XL880, GSK1363089), a novel inhibitor of HGF and VEGF receptor tyrosine kinases
F Qian, S Engst, K Yamaguchi, P Yu, KA Won, L Mock… - Cancer research, 2009 - AACR
The Met receptor tyrosine kinase and its ligand, hepatocyte growth factor (HGF), are
overexpressed and/or activated in a wide variety of human malignancies. Vascular …
overexpressed and/or activated in a wide variety of human malignancies. Vascular …
MET: a promising anticancer therapeutic target
S Peters, AA Adjei - Nature reviews Clinical oncology, 2012 - nature.com
The MET pathway is dysregulated in many human cancers and promotes tumour growth,
invasion and dissemination. Abnormalities in MET signalling have been reported to …
invasion and dissemination. Abnormalities in MET signalling have been reported to …