Prevalence of familial hypercholesterolemia among the general population and patients with atherosclerotic cardiovascular disease: a systematic review and meta …

P Hu, KI Dharmayat, CAT Stevens, MTA Sharabiani… - Circulation, 2020 - Am Heart Assoc
Background: Contemporary studies suggest that familial hypercholesterolemia (FH) is more
frequent than previously reported and increasingly recognized as affecting individuals of all …

Defining severe familial hypercholesterolaemia and the implications for clinical management: a consensus statement from the International Atherosclerosis Society …

RD Santos, SS Gidding, RA Hegele… - The lancet Diabetes & …, 2016 - thelancet.com
Familial hypercholesterolaemia is common in individuals who had a myocardial infarction at
a young age. As many as one in 200 people could have heterozygous familial …

Overview of the current status of familial hypercholesterolaemia care in over 60 countries-The EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC)

AJ Vallejo-Vaz, M De Marco, CAT Stevens, A Akram… - Atherosclerosis, 2018 - Elsevier
Background and aims Management of familial hypercholesterolaemia (FH) may vary across
different settings due to factors related to population characteristics, practice, resources …

Familial hypercholesterolaemia: evolving knowledge for designing adaptive models of care

GF Watts, SS Gidding, P Mata, J Pang… - Nature Reviews …, 2020 - nature.com
Optimal care for familial hypercholesterolaemia (FH) requires patient-centred management,
multidisciplinary teamwork, involvement of primary care practitioners, patient networks …

Analysis of differentially expressed genes and molecular pathways in familial hypercholesterolemia involved in atherosclerosis: a systematic and bioinformatics …

S Udhaya Kumar, D Thirumal Kumar, R Bithia… - Frontiers in …, 2020 - frontiersin.org
Background and Aims: Familial hypercholesterolemia (FH) is one of the major risk factor for
the progression of atherosclerosis and coronary artery disease. This study focused on …

Prevalence and predictors of cholesterol screening, awareness, and statin treatment among US adults with familial hypercholesterolemia or other forms of severe …

EM Bucholz, AM Rodday, K Kolor, MJ Khoury… - Circulation, 2018 - Am Heart Assoc
Background: Familial hypercholesterolemia (FH) and other extreme elevations in low-
density lipoprotein cholesterol significantly increase the risk of atherosclerotic …

Genetically confirmed familial hypercholesterolemia in patients with acute coronary syndrome

A Amor-Salamanca, S Castillo… - Journal of the American …, 2017 - jacc.org
Background: Genetic screening programs in unselected individuals with increased levels of
low-density lipoprotein cholesterol (LDL-C) have shown modest results in identifying …

Prognostic value of PCSK9 levels in patients with acute coronary syndromes

B Gencer, F Montecucco, D Nanchen… - European Heart …, 2016 - academic.oup.com
Aims Proprotein convertase subtilisin kexin 9 (PCSK9) is an emerging target for the
treatment of hypercholesterolaemia, but the clinical utility of PCSK9 levels to guide treatment …

Familial hypercholesterolemia among young adults with myocardial infarction

A Singh, A Gupta, BL Collins, A Qamar… - Journal of the American …, 2019 - jacc.org
Background: There are limited data on the prevalence and treatment of familial
hypercholesterolemia (FH) among US adults who experience a myocardial infarction (MI) at …

Prognosis of patients with familial hypercholesterolemia after acute coronary syndromes

D Nanchen, B Gencer, O Muller, R Auer, S Aghlmandi… - Circulation, 2016 - Am Heart Assoc
BACKGROUND: Patients with heterozygous familial hypercholesterolemia (FH) and
coronary heart disease have high mortality rates. However, in an era of high-dose statin …