Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Eukaryotic cells have been confronted throughout their evolution with potentially lethal
plasma membrane injuries, including those caused by osmotic stress, by infection from …

Zinc finger proteins are among the most abundant proteins in eukaryotic genomes. Their
functions are extraordinarily diverse and include DNA recognition, RNA packaging …

Zinc fingers (ZFs) are among the most structurally diverse protein domains. They interact
with nucleic acids, other proteins and lipids to facilitate a multitude of biological processes …

▪ Abstract The 3-phosphorylated inositol lipids fulfill roles as second messengers by
interacting with the lipid binding domains of a variety of cellular proteins. Such interactions …

Mdm2 has been shown to regulate p53 stability by targeting the p53 protein for proteasomal
degradation. We now report that Mdm2 is a ubiquitin protein ligase (E3) for p53 and that its …

The ESCRT machinery consists of the peripheral membrane protein complexes ESCRT-0,-I,-
II,-III, and Vps4–Vta1, and the ALIX homodimer. The ESCRT system is required for …

Many signaling pathways converge on and regulate phosphoinositide 3-kinase (PI3K)
enzymes whose inositol lipid products are key mediators of intracellular signaling. Different …

Autophagy is a lysosome-dependent cellular catabolic mechanism mediating the turnover of
intracellular organelles and long-lived proteins. Reduction of autophagy activity has been …

The ESCRT complexes and associated proteins comprise a major pathway for the
lysosomal degradation of transmembrane proteins and are critical for receptor …