The extracellular matrix (ECM) plays a key role as both structural scaffold and regulator of
cell signal transduction in tissues. In times of ECM assembly and turnover, cells upregulate …

Cells need to be anchored to extracellular matrix (ECM) to survive, yet the role of ECM in
guiding developmental processes, tissue homeostasis, and aging has long been …

Biophysical cues stemming from the extracellular environment are rapidly transduced into
discernible chemical messages (mechanotransduction) that direct cellular activities–placing …

According to the Chinese yin-yang concept, seemingly opposing forces give rise and
respond to each other. Opposing forces, whether passive or active, are also at work when …

Fibronectin fibrils within the extracellular matrix play central roles in physiological and
pathological processes, yet many structural details about their hierarchical and molecular …

Abstract Transglutaminase 2 (TG2) plays a vital role in stabilizing extracellular matrix (ECM)
proteins through enzymatic crosslinking during tissue growth, repair, and inflammation. TG2 …

Approximants to the inverse Langevin and Brillouin functions appear in diverse contexts
such as polymer science, molecular dynamics simulations, turbulence modeling …

Fibronectin is a critical component of the extracellular matrix and alterations to its structure
will influence cellular behavior. Matrix fibronectin is subjected to both mechanical and …

Cells and bacteria use mechanotransduction processes to transform a mechanical force into
a chemical/biochemical response. The area of chemistry where chemical reactions are …

Three-dimensional in vitro extracellular matrix models provide a physiological alternative to
regular two-dimensional cell culture, though they lack the full diversity of molecular …