Mechanical properties of extracellular matrices (ECMs) regulate essential cell behaviours,
including differentiation, migration and proliferation, through mechanotransduction. Studies …

Cells' local mechanical environment can be as important in guiding cellular responses as
many well-characterized biochemical cues. Hydrogels that mimic the native extracellular …

Substantial research over the past two decades has established that extracellular matrix
(ECM) elasticity, or stiffness, affects fundamental cellular processes, including spreading …

Mesenchymal stem cell (MSC) chondrogenesis in three-dimensional (3D) culture involves
dynamic changes in cytoskeleton architecture during mesenchymal condensation before …

The cell microenvironment has emerged as a key determinant of cell behavior and function
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …

Collective cancer invasion with leader–follower organization is increasingly recognized as a
predominant mechanism in the metastatic cascade. Leader cells support cancer invasion by …

The physical and architectural cues of the extracellular matrix (ECM) play a critical role in
regulating important cellular functions such as spreading, migration, proliferation, and …

Studies of cancer cell migration have found two modes: one that is protease-independent,
requiring micron-sized pores or channels for cells to squeeze through, and one that is …

Bioelectronics for modulating the nervous system have shown promise in treating
neurological diseases,–. However, their fixed dimensions cannot accommodate rapid tissue …

The mechanical properties of extracellular matrices can control the function of cells. Studies
of cellular responses to biomimetic soft materials have been largely restricted to hydrogels …