Cells and organisms must coordinate their metabolic activity with changes in their
environment to ensure their growth only when conditions are favourable. In order to maintain …

Defects in autophagy have been linked to a wide range of medical illnesses, including
cancer as well as infectious, neurodegenerative, inflammatory, and metabolic diseases …

Autophagy maintains cellular homeostasis during low energy states. According to the
current understanding, glucose-depleted cells induce autophagy through AMPK, the primary …

abstract ULK1 (unc-51 like autophagy activating kinase 1), the key mediator of MTORC1
signaling to autophagy, regulates early stages of autophagosome formation in response to …

Macroautophagy/autophagy, is widely recognized for its crucial role in enabling cell survival
and maintaining cellular energy homeostasis during starvation or energy stress. Its …

Lipid droplets (LDs) are reservoirs for triglycerides (TGs) and sterol-esters (SEs), but how
these lipids are organized within LDs and influence their proteome remain unclear. Using in …

Each cell is equipped with a conserved housekeeping mechanism, known as autophagy, to
recycle exhausted materials and dispose of injured organelles via lysosomal degradation …

Autophagy plays a critical role in cell metabolism by degrading and recycling internal
components when challenged with limited nutrients. This fundamental and conserved …

Niemann-Pick type C is a storage disease caused by dysfunction of NPC proteins, which
transport cholesterol from the lumen of lysosomes to the limiting membrane of that …

Cellular quiescence, the temporary and reversible exit from proliferative growth, is the
predominant state of all cells. However, our understanding of the biological processes and …