mTORC1 as the main gateway to autophagy
Y Rabanal-Ruiz, EG Otten… - Essays in biochemistry, 2017 - portlandpress.com
Cells and organisms must coordinate their metabolic activity with changes in their
environment to ensure their growth only when conditions are favourable. In order to maintain …
environment to ensure their growth only when conditions are favourable. In order to maintain …
Development of autophagy inducers in clinical medicine
Defects in autophagy have been linked to a wide range of medical illnesses, including
cancer as well as infectious, neurodegenerative, inflammatory, and metabolic diseases …
cancer as well as infectious, neurodegenerative, inflammatory, and metabolic diseases …
Redefining the role of AMPK in autophagy and the energy stress response
Autophagy maintains cellular homeostasis during low energy states. According to the
current understanding, glucose-depleted cells induce autophagy through AMPK, the primary …
current understanding, glucose-depleted cells induce autophagy through AMPK, the primary …
The ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating ATG14
abstract ULK1 (unc-51 like autophagy activating kinase 1), the key mediator of MTORC1
signaling to autophagy, regulates early stages of autophagosome formation in response to …
signaling to autophagy, regulates early stages of autophagosome formation in response to …
Interplay of energy metabolism and autophagy
Y Feng, Y Chen, X Wu, J Chen, Q Zhou, B Liu… - Autophagy, 2024 - Taylor & Francis
Macroautophagy/autophagy, is widely recognized for its crucial role in enabling cell survival
and maintaining cellular energy homeostasis during starvation or energy stress. Its …
and maintaining cellular energy homeostasis during starvation or energy stress. Its …
Triglyceride lipolysis triggers liquid crystalline phases in lipid droplets and alters the LD proteome
Lipid droplets (LDs) are reservoirs for triglycerides (TGs) and sterol-esters (SEs), but how
these lipids are organized within LDs and influence their proteome remain unclear. Using in …
these lipids are organized within LDs and influence their proteome remain unclear. Using in …
[HTML][HTML] The beneficial and adverse effects of autophagic response to caloric restriction and fasting
R Shabkhizan, S Haiaty, MS Moslehian, A Bazmani… - Advances in …, 2023 - Elsevier
Each cell is equipped with a conserved housekeeping mechanism, known as autophagy, to
recycle exhausted materials and dispose of injured organelles via lysosomal degradation …
recycle exhausted materials and dispose of injured organelles via lysosomal degradation …
Advances in autophagy regulatory mechanisms
LE Gallagher, LE Williamson, EYW Chan - Cells, 2016 - mdpi.com
Autophagy plays a critical role in cell metabolism by degrading and recycling internal
components when challenged with limited nutrients. This fundamental and conserved …
components when challenged with limited nutrients. This fundamental and conserved …
Niemann-Pick type C proteins promote microautophagy by expanding raft-like membrane domains in the yeast vacuole
T Tsuji, M Fujimoto, T Tatematsu, J Cheng, M Orii… - Elife, 2017 - elifesciences.org
Niemann-Pick type C is a storage disease caused by dysfunction of NPC proteins, which
transport cholesterol from the lumen of lysosomes to the limiting membrane of that …
transport cholesterol from the lumen of lysosomes to the limiting membrane of that …