Context: Vitamin B12 deficiency may occur with metformin treatment, but few studies have
assessed risk with long-term use. Objective: To assess the risk of B12 deficiency with …

Aims Metformin treatment is associated with a decrease of serum vitamin B12, but whether
this reflects tissue B12 deficiency is controversial. We studied the effects of metformin on …

BACKGROUND Metformin is arguably the most commonly prescribed oral hypoglycemic
agent for the management of diabetes. Due to the lack of randomized control trials, most of …

Background: Vitamin B12 deficiency is a common condition causing neurologic, cognitive,
psychiatric, and mood symptoms. With varied religious, ethnic, and socioeconomic …

Metformin is the only biguanide derivative used to treat type 2 diabetes mellitus (T2D).
Several studies documented that its use contributes to vitamin B12 deficiency in 10–30% of …

Purpose Metformin is a common medication for patients with hyperglycemia. In adults, one
well-documented side effect of metformin is vitamin B12 deficiency. However, this side effect …

Metformin belongs to biguanide class of compound and is an approved drug for the
treatment of type II diabetes. Besides, metformin can prevent the occurrence of other …

Background: Metformin-induced vitamin B12 deficiency was shown by several studies with a
prevalence estimate ranging from 5.8% to 52%. Objectives: This study aimed to assess the …

Aims The study aimed at assessing the prevalence and clinical features of vitamin B12
deficiency in hypothyroid patients and to evaluate clinical response to vitamin B12 …

According to reports from the World Health Organization, the aging population in both
developed and in developing countries it has been possible due an improvement in access …