Recent antimalarial drug discovery has been a race to produce new medicines that
overcome emerging drug resistance, whilst considering safety and improving dosing …

The intracellular protozoan parasite of the genus Cryptosporidium is among the leading
causes of waterborne diarrheal disease outbreaks throughout the world. The parasite is …

Abstract The IUPHAR/BPS Guide to PHARMACOLOGY (www. guidetopharmacology. org) is
an open-access, expert-curated database of molecular interactions between ligands and …

Cryptosporidium emerged as a leading global cause of severe diarrheal disease in children.
The parasite occupies a unique intracellular niche at the brush border of intestinal epithelial …

The replacement of one chemical motif with another that is broadly similar is a common
method in medicinal chemistry to modulate the physical and biological properties of a …

The timelines for developing vaccines against infectious diseases are lengthy, and often
vaccines that reach the stage of large phase 3 field trials fail to provide the desired level of …

Parasites and their hosts are engaged in reciprocal coevolution that balances competing
mechanisms of virulence, resistance, and evasion. This often leads to host specificity, but …

The Malaria Drug Accelerator (MalDA) is a consortium of 15 leading scientific laboratories.
The aim of MalDA is to improve and accelerate the early antimalarial drug discovery process …

Aminoacyl-tRNA synthetases (ARSs) play a vital role in protein synthesis by linking amino
acids to their cognate transfer RNAs (tRNAs). This typical function has been well recognized …

Aminoacyl-tRNA synthetases (ARSs) catalyze the ligation of amino acids to their cognate
transfer RNAs (tRNAs), thus playing an important role in protein synthesis. In eukaryotic …