This article represents the first in a series of tutorials on model evaluation in nonlinear mixed
effect models (NLMEMs), from the International Society of Pharmacometrics (ISoP) Model …

Informative diagnostic tools are vital to the development of useful mixed-effects models. The
Visual Predictive Check (VPC) is a popular tool for evaluating the performance of population …

Wide-Ranging Coverage of Parametric Modeling in Linear and Nonlinear Mixed Effects
Models Mixed Effects Models for the Population Approach: Models, Tasks, Methods and …

The saemix package for R provides maximum likelihood estimates of parameters in
nonlinear mixed effect models, using a modern and efficient estimation algorithm, the …

Background Opioids can produce life-threatening respiratory depression. This study tested
whether subanaesthetic doses of esketamine stimulate breathing in an established human …

Background: To improve understanding of the respiratory behavior of oliceridine, a μ-opioid
receptor agonist that selectively engages the G-protein–coupled signaling pathway with …

Chronic opioid consumption is associated with addiction, physical dependence, and
tolerance. Tolerance results in dose escalation to maintain the desired opioid effect. Intake …

Favipiravir is an RNA polymerase inhibitor that showed strong antiviral efficacy in vitro and
in small-animal models of several viruses responsible for hemorrhagic fever (HF), including …

Purpose For nonlinear mixed-effects pharmacometric models, diagnostic approaches often
rely on individual parameters, also called empirical Bayes estimates (EBEs), estimated …

Background: Esketamine is traditionally administered via intravenous or intramuscular
routes. In this study we developed a pharmacokinetic model of inhalation of nebulized …