Antibacterial agents: high-potency myxopyronin derivatives

RH Ebright, YW Ebright - US Patent 9,133,155, 2015 - Google Patents
Bacterial infectious diseases kill 100,000 persons each year in the US and 11 million
persons each year worldwide, representing nearly a fifth of deaths each year worldwide …

Antibacterial agents: sidechainfluorinated myxopyronin derivatives

RH Ebright, YW Ebright - US Patent 9,187,446, 2015 - Google Patents
The invention provides compounds of Formula I: and pharmaceutically acceptable salts
thereof, wherein R', RRRR and Gare as described in the specification, as well as …

Antibacterial agents: phloroglucinol derivatives

RH Ebright, J Shen - US Patent 9,517,994, 2016 - Google Patents
US9517994B2 - Antibacterial agents: phloroglucinol derivatives - Google Patents
US9517994B2 - Antibacterial agents: phloroglucinol derivatives - Google Patents …

Antibacterial agents: aryl myxopyronin derivatives

RH Ebright, YW Ebright, J Shen, J Bacci… - US Patent …, 2016 - Google Patents
The invention provides compounds of formula la, lb and Ic:[Formula Ia, Ib, and Ic] and salts
thereof, wherein variables are as described in the specification, as well as compositions …

Inhibitors of bacterial RNA polymerase: arylpropanoyl, arylpropenoyl, and arylcyclopropanecarboxyl phloroglucinols

RH Ebright, J Freundlich, N Mittal… - US Patent …, 2019 - Google Patents
US10450292B2 - Inhibitors of bacterial RNA polymerase: arylpropanoyl, arylpropenoyl, and
arylcyclopropanecarboxyl phloroglucinols - Google Patents US10450292B2 - Inhibitors of …

Antibacterial agents: aryl myxopyronin derivatives

RH Ebright, YW Ebright, J Shen, J Bacci… - US Patent …, 2017 - Google Patents
Ic and salts thereof, wherein variables are as described in the specification, as well as
compositions comprising a com pound of formula Ia-Ic, methods of making Such com …

Antibacterial agents: o-alkyl-deuterated pyronins

RH Ebright, YW Ebright - US Patent 11,685,723, 2023 - Google Patents
The invention provides compounds of formula Ia, Ib, Ic, or as well as compositions
comprising a compound of formula Ia-Id, methods of making such compounds, and methods …

Antibacterial agents: arylalkylcarboxamido phloroglucinols

RH Ebright, YW Ebright, JS Freundlich… - US Patent …, 2023 - Google Patents
The invention provides compounds of formula (I) or (II) and tautomers and salts thereof,
wherein variables are as described in the specification, as well as compositions comprising …