The main inherited cardiac arrhythmias are long QT syndrome, short QT syndrome,
catecholaminergic polymorphic ventricular tachycardia and Brugada syndrome. These rare …

There has been a significant progress in our understanding of the molecular mechanisms by
which calcium (Ca2+) ions mediate various types of cardiac arrhythmias. A growing list of …

The Japanese Circulation Society (JCS) published the “Guidelines for Pharmacological
Treatment of Arrhythmia” in 2004, and a revised edition was published in 2009. 1 Both …

Background: Among his major cardiac electrophysiological contributions, Miles Vaughan
Williams (1918–2016) provided a classification of antiarrhythmic drugs that remains central …

Carvedilol is among the most effective β-blockers for improving survival after myocardial
infarction. Yet the mechanisms by which carvedilol achieves this superior clinical profile are …

Cardiac ryanodine receptor (RyR2) gain-of-function mutations cause catecholaminergic
polymorphic ventricular tachycardia, a condition characterized by prominent ventricular …

Management strategies for ventricular arrhythmias are guided by the risk of sudden death
and severity of symptoms. Patients with a substantial risk of sudden death usually need an …

Atrial fibrillation (AF) is an extremely common clinical problem associated with increased
morbidity and mortality. Current antiarrhythmic options include pharmacological, ablation …

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, and its prevalence is
increasing with the ageing of the population. Presently available treatment options are far …

Heart failure is a complex clinical syndrome characterized by insufficient cardiac function. In
addition to abnormalities intrinsic to the heart, dysfunction of other organs and dysregulation …